Homo sapiens Gene: MIR223
Summary
InnateDB Gene IDBG-127311.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MIR223
Gene Name microRNA 223
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000207939
Encoded Proteins
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
MIR223 negatively regulates NLRP3 inflammasome activity.
MIR223 regulates the NLRP3 inflammasome and IL-1β production.
MIR223 regulates macrophage function by modulating cytokine production and NF-κB activation through inhibition of RELA phosphorylation and nuclear translocation.
Entrez Gene
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Gene Information
Type miRNA
Genomic Location Chromosome X:66018870-66018979
Strand Forward strand
Band q12
Transcripts
ENST00000385204
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 3 [view]
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 407008
UniGene Hs.38218
RefSeq
HUGO HGNC:31603
OMIM 300694
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 407008