InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Med14

Summary

InnateDB Gene

IDBG-132282.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Med14

Gene Name

mediator complex subunit 14

Synonyms

9930001L01Rik; AU041628; Crsp2; ENSMUSG00000073278; Gm641; ORF1; Trap170

Species

Mus musculus

Ensembl Gene

ENSMUSG00000064127

Encoded Proteins

IDBP-132284

mediator complex subunit 14

IDBP-132286

mediator complex subunit 14

IDBP-249509

mediator complex subunit 14

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180182:
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:12675369-12762073

Strand

Reverse strand

Band

A1.1

Transcripts

ENSMUST00000076016	ENSMUSP00000075395
ENSMUST00000096495	ENSMUSP00000094239
ENSMUST00000115481	ENSMUSP00000111143
ENSMUST00000124053
ENSMUST00000124070

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	67 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0004872	receptor activity
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0019827	stem cell maintenance
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter