InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Map3k11

Summary

InnateDB Gene

IDBG-132706.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map3k11

Gene Name

mitogen-activated protein kinase kinase kinase 11

Synonyms

2610017K16Rik; Mlk3; PTK1; SPRK

Species

Mus musculus

Ensembl Gene

ENSMUSG00000004054

Encoded Proteins

IDBP-132708

mitogen-activated protein kinase kinase kinase 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173327:
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:5689131-5702862

Strand

Forward strand

Band

Transcripts

ENSMUST00000004156

ENSMUSP00000004156

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004706	JUN kinase kinase kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0048365	Rac GTPase binding

Biological Process

GO:0000080	mitotic G1 phase
GO:0000187	activation of MAPK activity
GO:0006468	protein phosphorylation
GO:0007017	microtubule-based process
GO:0007254	JNK cascade
GO:0007256	activation of JNKK activity
GO:0007257	activation of JUN kinase activity
GO:0008219	cell death
GO:0008283	cell proliferation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0043065	positive regulation of apoptotic process
GO:0043507	positive regulation of JUN kinase activity
GO:0043525	positive regulation of neuron apoptotic process
GO:0046330	positive regulation of JNK cascade
GO:0046777	protein autophosphorylation