Mus musculus Gene: Ikbkb
Summary
InnateDB Gene IDBG-141021.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ikbkb
Gene Name inhibitor of kappaB kinase beta
Synonyms AI132552; IKK-2; IKK-beta; IKK[b]; IKK2; IKKbeta;
Species Mus musculus
Ensembl Gene ENSMUSG00000031537
Encoded Proteins
inhibitor of kappaB kinase beta
inhibitor of kappaB kinase beta
inhibitor of kappaB kinase beta
inhibitor of kappaB kinase beta
inhibitor of kappaB kinase beta
inhibitor of kappaB kinase beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Ikbkb and other IKK kinases regulate each other by an intricate network involving phosphorylation of their catalytic and regulatory (NEMO, TANK) subunits to balance their activities during innate immunity.
The reversible ubiquitin editing of Nlrc5 determines Nlrc5?? Ikbkb interaction dynamics and plays a crucial role in precisely regulating NFκB signalling
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] IKBKB regulates late-phase allergic reactions promoted by the release of pro-inflammatory cytokines in an NF-kappaB-dependent manner.
[Homo sapiens] Phosphorylated IKBKB is conjugated with a monoubiquitin by the E3 ubiquitin ligase TRIM21 leading to down-regulatioin of IKBKB-induced NF-kappaB signalling. The TRIM21-mediated monoubiquitination is involved in the translocation of active IKBKB to autophagosomes.
[Homo sapiens] IKBKB and other IKK kinases regulate each other by an intricate network involving phosphorylation of their catalytic and regulatory (NEMO, TANK) subunits to balance their activities during innate immunity.
[Homo sapiens] GNB2L1 (RACK1) negatively regulates NFκB activation by interacting with CHUK and IKBKB. The interaction interferes with the recruitment of the IKK complex to TRAF2 .
[Homo sapiens] The reversible ubiquitin editing of NLRC5 determines NLRC5?? IKBKB interaction dynamics and plays a crucial role in precisely regulating NFκB signalling
[Homo sapiens] Enterovirus 71 2C protein binds to RELA and IKBKB to inhibit NF-kB activation and evade innate immune defenses.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104365:
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:22659212-22706589
Strand Reverse strand
Band A2
Transcripts
ENSMUST00000033939 ENSMUSP00000033939
ENSMUST00000063401 ENSMUSP00000064235
ENSMUST00000125314 ENSMUSP00000138156
ENSMUST00000135326 ENSMUSP00000138378
ENSMUST00000132279 ENSMUSP00000120049
ENSMUST00000146212
ENSMUST00000126496
ENSMUST00000150259
ENSMUST00000144583
ENSMUST00000131767 ENSMUSP00000120916
ENSMUST00000144895
ENSMUST00000126439
ENSMUST00000149093
ENSMUST00000150214
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 169 interaction(s) predicted by orthology.
Experimentally validated
Total 75 [view]
Protein-Protein 72 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 169 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008384 IkappaB kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0019901 protein kinase binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0097110 scaffold protein binding
Biological Process
GO:0001782 B cell homeostasis
GO:0006468 protein phosphorylation
GO:0007252 I-kappaB phosphorylation
GO:0009103 lipopolysaccharide biosynthetic process
GO:0010765 positive regulation of sodium ion transport
GO:0023014 signal transduction by phosphorylation
GO:0042501 serine phosphorylation of STAT protein
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0071356 cellular response to tumor necrosis factor
GO:2001259 positive regulation of cation channel activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0009898 cytoplasmic side of plasma membrane
GO:0016020 membrane
GO:0035631 CD40 receptor complex
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
TRAF6 mediated NF-kB activation pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream TCR signaling pathway
MyD88 cascade initiated on plasma membrane pathway
FCERI mediated NF-kB activation pathway
Cytokine Signaling in Immune system pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Activation of NF-kappaB in B cells pathway
p75NTR recruits signalling complexes pathway
Fc epsilon receptor (FCERI) signaling pathway
Toll-Like Receptors Cascades pathway
Signaling by Interleukins pathway
NOD1/2 Signaling Pathway pathway
p75NTR signals via NF-kB pathway
MyD88 dependent cascade initiated on endosome pathway
Cytosolic sensors of pathogen-associated DNA pathway
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway
Signalling by NGF pathway
RIP-mediated NFkB activation via ZBP1 pathway
Adaptive Immune System pathway
NF-kB is activated and signals survival pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Activated TLR4 signalling pathway
IKK complex recruitment mediated by RIP1 pathway
Interleukin-1 signaling pathway
MyD88-independent cascade pathway
Signal Transduction pathway
p75 NTR receptor-mediated signalling pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
TCR signaling pathway
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
IRAK1 recruits IKK complex pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
MAPK signaling pathway pathway
Chemokine signaling pathway pathway
mTOR signaling pathway pathway
Apoptosis pathway
Osteoclast differentiation pathway
Toll-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Neurotrophin signaling pathway pathway
Insulin signaling pathway pathway
Adipocytokine signaling pathway pathway
Type II diabetes mellitus pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Hepatitis C pathway
Pathways in cancer pathway
Pancreatic cancer pathway
Prostate cancer pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Small cell lung cancer pathway
INOH
TNFR1 signaling pathway pathway
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TGF_beta_Receptor pathway
TNFalpha pathway
TCR pathway
BCR pathway
IL1 pathway
IL4 pathway
RANKL pathway
Leptin pathway
TSH pathway
TWEAK pathway
IL11 pathway
REACTOME
RIP-mediated NFkB activation via ZBP1 pathway
MyD88 dependent cascade initiated on endosome pathway
FCERI mediated NF-kB activation pathway
Signalling by NGF pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
p75NTR recruits signalling complexes pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TCR signaling pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
MyD88 cascade initiated on plasma membrane pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
NF-kB is activated and signals survival pathway
IKK complex recruitment mediated by RIP1 pathway
IRAK1 recruits IKK complex pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
TRAF6 mediated NF-kB activation pathway
Fc epsilon receptor (FCERI) signaling pathway
p75 NTR receptor-mediated signalling pathway
p75NTR signals via NF-kB pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Signal Transduction pathway
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway
Activation of NF-kappaB in B cells pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Adaptive Immune System pathway
NOD1/2 Signaling Pathway pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Immune System pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Signaling by Interleukins pathway
Downstream TCR signaling pathway
Interleukin-1 signaling pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Cytosolic sensors of pathogen-associated DNA pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
NOD1/2 Signaling Pathway pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Activated TLR4 signalling pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88-independent cascade pathway
Cytosolic sensors of pathogen-associated DNA pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
IKK complex recruitment mediated by RIP1 pathway
Cytokine Signaling in Immune system pathway
Downstream TCR signaling pathway
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Toll-Like Receptors Cascades pathway
Signal Transduction pathway
TRAF6 mediated NF-kB activation pathway
NF-kB is activated and signals survival pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
p75NTR recruits signalling complexes pathway
Signalling by NGF pathway
FCERI mediated NF-kB activation pathway
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
Adaptive Immune System pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Activation of NF-kappaB in B cells pathway
MyD88 dependent cascade initiated on endosome pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
p75 NTR receptor-mediated signalling pathway
Innate Immune System pathway
Interleukin-1 signaling pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
RIP-mediated NFkB activation via ZBP1 pathway
Signaling by Interleukins pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
IRAK1 recruits IKK complex pathway
MyD88 cascade initiated on plasma membrane pathway
TCR signaling pathway
p75NTR signals via NF-kB pathway
KEGG
MAPK signaling pathway pathway
Chemokine signaling pathway pathway
mTOR signaling pathway pathway
Apoptosis pathway
Osteoclast differentiation pathway
Toll-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Neurotrophin signaling pathway pathway
Insulin signaling pathway pathway
Adipocytokine signaling pathway pathway
Type II diabetes mellitus pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Shigellosis pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Hepatitis C pathway
Pathways in cancer pathway
Pancreatic cancer pathway
Prostate cancer pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Small cell lung cancer pathway
INOH
TNFR1 signaling pathway pathway
IL-7 signaling pathway
CD4 T cell receptor signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Toll-like receptor pathway [Biocarta view]
Chaperones modulate interferon signaling pathway [Biocarta view]
Nf-kb signaling pathway [Biocarta view]
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
Inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages [Biocarta view]
Keratinocyte differentiation [Biocarta view]
Bone remodeling [Biocarta view]
Double stranded rna induced gene expression [Biocarta view]
Trefoil factors initiate mucosal healing [Biocarta view]
Signal transduction through il1r [Biocarta view]
Tnf/stress related signaling [Biocarta view]
Mapkinase signaling pathway [Biocarta view]
Ceramide signaling pathway [Biocarta view]
Nfkb activation by nontypeable hemophilus influenzae [Biocarta view]
Influence of ras and rho proteins on g1 to s transition [Biocarta view]
PID NCI
Atypical NF-kappaB pathway
TCR signaling in nave CD8+ T cells
TCR signaling in nave CD4+ T cells
IL1-mediated signaling events
TNF receptor signaling pathway
TRAIL signaling pathway
mTOR signaling pathway
FoxO family signaling
p75(NTR)-mediated signaling
BCR signaling pathway
Canonical NF-kappaB pathway
GMCSF-mediated signaling events
Validated transcriptional targets of TAp63 isoforms
Fc-epsilon receptor I signaling in mast cells
Endogenous TLR signaling
FAS (CD95) signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 16150
UniGene Mm.277886 Mm.401349
RefSeq NM_001159774 NM_010546 XM_006509020 XM_006509021 XM_006509022 XM_006509023
OMIM
CCDS CCDS22182 CCDS52522
HPRD
IMGT
MGI ID MGI:1338071
MGI Symbol Ikbkb
EMBL
GenPept
RNA Seq Atlas 16150