Version 5.4
Mus musculus Gene: Fcrl5
Summary
InnateDB Gene IDBG-157234.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fcrl5
Gene Name Fc receptor-like 5
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000048031
Encoded Proteins
IDBP-157236
Fc receptor-like 5
IDBP-620082
Fc receptor-like 5
IDBP-717319
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20519648
Fcrl5 is an orphan immunoregulatory protein that is highly expressed by innate B lymphocytes, as a specific receptor for orthopoxvirus MHC class I-like protein (OMCP) and this strongly implicates it in contributing to host defense against zoonotic orthopoxviruses.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:87435885-87457836
Strand Forward strand
Band F1
Transcripts
ENSMUST00000049926 ENSMUSP00000050151
ENSMUST00000166297 ENSMUSP00000131176
ENSMUST00000178261 ENSMUSP00000136046
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0045087 innate immune response (InnateDB)
GO:0050859 negative regulation of B cell receptor signaling pathway
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q68SN8
TrEMBL J3QJU0
UniProt Splice Variant
Entrez Gene 329693
UniGene Mm.331122
RefSeq NM_001113238 NM_183222
OMIM
CCDS CCDS50943 CCDS50944
HPRD
IMGT
MGI ID MGI:3053558
MGI Symbol Fcrl5
EMBL AC163618 AK089756 AY158090 AY506558
GenPept AAO20873 AAS91578 BAC40954
RNA Seq Atlas 329693

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca