Version 5.4
Mus musculus Gene: Usp25
Summary
InnateDB Gene IDBG-171582.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Usp25
Gene Name ubiquitin specific peptidase 25
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000022867
Encoded Proteins
IDBP-171584
ubiquitin specific peptidase 25
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 26305951
Usp25 physically associates with Traf3 and Traf6 after infection by RNA or DNA viruses and promotes innate antiviral responses by protecting virus-induced proteasome-dependent or independent degradation of Traf3 and Traf6.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155313:
Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:77014069-77116779
Strand Forward strand
Band C3.1
Transcripts
ENSMUST00000023580 ENSMUSP00000023580
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0032183 SUMO binding
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0045087 innate immune response (InnateDB)
GO:0070536 protein K63-linked deubiquitination
GO:0071108 protein K48-linked deubiquitination
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000155313
View Gene Order
ENSBTAG00000019314
Not yet available
Cross-References
SwissProt P57080
TrEMBL Q8BR08 Q8CBA4 Q9CSW6
UniProt Splice Variant
Entrez Gene 30940
UniGene Mm.397385 Mm.40986
RefSeq NM_013918
OMIM
CCDS CCDS28275
HPRD
IMGT
MGI ID MGI:1353655
MGI Symbol Usp25
EMBL AF170563 AK011798 AK036456 AK045966 BC048171 BC063059
GenPept AAF32264 AAH48171 AAH63059 BAB27849 BAC29438 BAC32550
RNA Seq Atlas 30940

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca