Version 5.4
| Mus musculus Gene: Tank | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-173742.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Tank | ||||||||||||||||||||||
| Gene Name | TRAF family member-associated Nf-kappa B activator | ||||||||||||||||||||||
| Synonyms | C86182; E430026L09Rik; I-TRAF | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000064289 | ||||||||||||||||||||||
| Encoded Proteins |
TRAF family member-associated Nf-kappa B activator
TRAF family member-associated Nf-kappa B activator
TRAF family member-associated Nf-kappa B activator
TRAF family member-associated Nf-kappa B activator
TRAF family member-associated Nf-kappa B activator
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||
| Summary |
Tank plays a key role in the cross-talk between the IKK-related and the canonical IKK kinases, a mechanism required to limit the strength of TLR-signalling and prevent autoimmunity.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||||||
| Summary |
[Homo sapiens] TANK is involved in interferon responses and is a negative regulator of pro-inflammatory cytokine production induced by TLR signalling.
[Homo sapiens] TANK plays a key role in the cross-talk between the IKK-related and the canonical IKK kinases, a mechanism required to limit the strength of TLR-signalling and prevent autoimmunity. (Demonstrated in mice)
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| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136560:
The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 2:61578585-61654171 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | C1.3 | ||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Toll Like Receptor 3 (TLR3) Cascade pathway
Innate Immune System pathway
Immune System pathway
TRAF6 mediated IRF7 activation pathway
Toll-Like Receptors Cascades pathway
Activated TLR4 signalling pathway
MyD88-independent cascade pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG |
RIG-I-like receptor signaling pathway pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH |
TNFalpha pathway
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| REACTOME |
TRAF6 mediated IRF7 activation pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Immune System pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
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| KEGG |
RIG-I-like receptor signaling pathway pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| UniGene | Mm.244393 Mm.465720 | ||||||||||||||||||||||
| RefSeq | NM_001164071 NM_001164072 NM_011529 XM_006499087 XM_006499088 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS16061 CCDS50592 CCDS50593 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||