Mus musculus Gene: Il1a | |||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-205910.6 | ||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||
Gene Symbol | Il1a | ||||||||||||||||||||||||||||||||||
Gene Name | interleukin 1 alpha | ||||||||||||||||||||||||||||||||||
Synonyms | Il-1a | ||||||||||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000027399 | ||||||||||||||||||||||||||||||||||
Encoded Proteins |
interleukin 1 alpha
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Protein Structure | |||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||||||||||
Summary |
Under acidic conditions both pro-inflammatory forms of Il1a and Il1b are regulated independently of the NLRP3 inflammasome.
In response to adenovirus infection, the IL1A-IL1R1-CXCR2 signalling axis cooperates with complement to recruit Ly-6G+7/4+ polymorphonuclear leukocytes to the splenic marginal zone (MZ) in the proximity of virus-containing MARCO+ residential MZ macrophages, which are subsequently eliminated.
NLRP3 inflammasome formation is dispensable for alum-induced innate immunity but Il1a and Il1b are both necessary for alum-induced neutrophil influx in vivo.
Il1a directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||
Summary |
[Homo sapiens] Interleukin-1 (IL1A/IL1B) plays a key role in the interaction between local vessel wall cells and invading monocytes to multiply cholesterol-triggered inflammation in the vessel wall.
[Homo sapiens] IFNG interferes with the IL-1/NFKBIZ axis in β-glucan-activated dendritic cells and promotes T cell-mediated immune responses with increased release of IFNG and IL22, and diminished production of IL17A.
[Homo sapiens] CASP4 is a critical regulator of noncanonical inflammasome activation that initiates defence against bacterial pathogens in primary macrophages by mediating cell death and IL1A release
[Homo sapiens] IL1A directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
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Entrez Gene | |||||||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115008:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008] The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer\'s disease. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 2:129299610-129309972 | ||||||||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||||||||
Band | F1 | ||||||||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||||
REACTOME |
Cytokine Signaling in Immune system pathway
Immune System pathway
Signaling by Interleukins pathway
Interleukin-1 signaling pathway
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KEGG |
Cytokine-cytokine receptor interaction pathway
Type I diabetes mellitus pathway
Hematopoietic cell lineage pathway
MAPK signaling pathway pathway
Apoptosis pathway
Graft-versus-host disease pathway
Prion diseases pathway
Leishmaniasis pathway
Osteoclast differentiation pathway
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INOH |
IL-1 signaling pathway pathway
JAK STAT pathway and regulation pathway
GPCR signaling pathway
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PID NCI | |||||||||||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||
NETPATH |
IL1 pathway
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REACTOME |
Interleukin-1 signaling pathway
Interleukin-1 processing pathway
Cellular responses to stress pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Cellular Senescence pathway
Signaling by Interleukins pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Interleukin-1 signaling pathway
Signaling by Interleukins pathway
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KEGG |
Hematopoietic cell lineage pathway
Apoptosis pathway
MAPK signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Type I diabetes mellitus pathway
Graft-versus-host disease pathway
Prion diseases pathway
Leishmaniasis pathway
Osteoclast differentiation pathway
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INOH |
IL-1 signaling pathway pathway
JAK STAT pathway and regulation pathway
GPCR signaling pathway
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PID NCI |
IL1-mediated signaling events
a6b1 and a6b4 Integrin signaling
Validated transcriptional targets of deltaNp63 isoforms
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Cross-References | |||||||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||
UniGene | Mm.15534 | ||||||||||||||||||||||||||||||||||
RefSeq | NM_010554 XM_006498792 XM_006498793 | ||||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||||
CCDS | CCDS16725 | ||||||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||||||||