Homo sapiens Gene: NLRC5 | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Gene | IDBG-32729.6 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | NLRC5 | ||||||||||||||||||||
Gene Name | NLR family, CARD domain containing 5 | ||||||||||||||||||||
Synonyms | |||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||
Ensembl Gene | ENSG00000140853 | ||||||||||||||||||||
Encoded Proteins |
NLR family, CARD domain containing 5
NLR family, CARD domain containing 5
NLR family, CARD domain containing 5
NLR family, CARD domain containing 5
NLR family, CARD domain containing 5
NLR family, CARD domain containing 5
NLR family, CARD domain containing 5
NLR family, CARD domain containing 5
NLR family, CARD domain containing 5
NLR family, CARD domain containing 5
NLR family, CARD domain containing 5
NLR family, CARD domain containing 5
NLR family, CARD domain containing 5
NLR family, CARD domain containing 5
NLR family, CARD domain containing 5
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Protein Structure | |||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||
Summary |
NLRC5 is nn NLR (nucleotide-binding domain and leucine-rich repeat containing family receptors) that is part of the family of pattern recognition receptors (PRRs) and is involved in immunity against intracellular pathogens.
NLRC5 represents a molecular switch of IFN-gamma activation sequence/IFN-specific response element signalling pathways contributing to antiviral defence mechanisms.
NLRC5 is a negative regulator that blocks two central components of the NF-kappaB and type I interferon signalling pathways and has an important role in homeostatic control of innate immunity.
NLRC5 is dispensable for cytokine induction in virus and bacterial infections under physiologic conditions. (Demonstrated in murine model)
The reversible ubiquitin editing of NLRC5 determines NLRC5â?? IKBKB interaction dynamics and plays a crucial role in precisely regulating NFκB signalling
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Entrez Gene | |||||||||||||||||||||
Summary |
This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011] |
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Gene Information | |||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||
Genomic Location | Chromosome 16:56989485-57083531 | ||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||
Band | q13 | ||||||||||||||||||||
Transcripts | |||||||||||||||||||||
Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||
No orthologs found for this gene | |||||||||||||||||||||
Pathways | |||||||||||||||||||||
NETPATH | |||||||||||||||||||||
REACTOME |
Negative regulators of RIG-I/MDA5 signaling pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Innate Immune System pathway
Immune System pathway
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KEGG | |||||||||||||||||||||
INOH | |||||||||||||||||||||
PID NCI | |||||||||||||||||||||
Cross-References | |||||||||||||||||||||
SwissProt | |||||||||||||||||||||
TrEMBL | |||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||
UniGene | Hs.528836 Hs.708775 | ||||||||||||||||||||
RefSeq | NM_032206 XM_005256193 XM_005256194 XM_005256195 XM_005256197 XM_005256199 XM_005256200 XM_006721297 XM_006721300 | ||||||||||||||||||||
HUGO | |||||||||||||||||||||
OMIM | |||||||||||||||||||||
CCDS | CCDS10773 | ||||||||||||||||||||
HPRD | 14831 | ||||||||||||||||||||
IMGT | |||||||||||||||||||||
EMBL | |||||||||||||||||||||
GenPept | |||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||