InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IRF1

Summary

InnateDB Gene

IDBG-42125.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IRF1

Gene Name

interferon regulatory factor 1

Synonyms

IRF-1; MAR

Species

Homo sapiens

Ensembl Gene

ENSG00000125347

Encoded Proteins

IDBP-42129

interferon regulatory factor 1

IDBP-293081

interferon regulatory factor 1

IDBP-376299

interferon regulatory factor 1

IDBP-376300

interferon regulatory factor 1

IDBP-376301

interferon regulatory factor 1

IDBP-807184

interferon regulatory factor 1

IDBP-807186

interferon regulatory factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 12759449

IRF1 is required for the up-regulation of the CD40-NF-kappaB activator 1 (TRAF3IP2 ) axis during airway inflammation.

PMID 12420214

IRF1 is controlled by two distinct signalling pathways; a JAK/STAT-signalling pathway in viral infected cells and an ATM-signalling pathway in DNA damaged cells.

PMID 3409321

IRF1 specifically binds to the upstream regulatory region of the human IFN-beta (IFNB1) gene and mediates IFNB1 virus-induced transcription and is involved in the regulation of other genes such as IFN-alpha and MHC class I genes.

PMID 20308629

IRF1 mediated type I IFN independent mechanism of enhanced RSAD2 (viperin) expression provides a redundant mechanism to protect cells from viral infections.

PMID 21097874

IRF1 transcriptionally inhibits the IL23A through the ISRE element and reduce the severity of chronic intestinal inflammation caused by LPS (shown in mice).

PMID 22266972

IRF1 promotes immune cell apoptosis and inhibits autophagy in a murine endotoxemia model. (Demonstrated in mice)

PMID 25461762

MIR23A contributes to human herpes simplex virus type 1 replication through the regulation of the IRF1-mediated antiviral signal pathway.

InnateDB Annotation from Orthologs

Summary

PMID 21097874

[Mus musculus] Irf1 transcriptionally inhibits the Il23a through the ISRE element and reduce the severity of chronic intestinal inflammation caused by LPS.

PMID 22266972

[Mus musculus] Irf1 promotes immune cell apoptosis and inhibits autophagy in a murine endotoxemia model.

PMID 24675692

[Mus musculus] Irf1 is an essential regulator of the host innate antiviral response in the brain by limiting viral replication at later stages of infection, but is not involved in the rapid induction of IFN.

PMID 26305961

[Mus musculus] Nlrp3 deficiency protects mice from the development of type 1 diabetes by suppressing Th1 responses and impairing T-cell migration to pancreatic islets through the down-regulation of chemokine expression (Ccl5, Cxcl10, Irf1) in islets.

Entrez Gene

Summary

IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:132481609-132490798

Strand

Reverse strand

Band

q31.1

Transcripts

ENST00000245414	ENSP00000245414
ENST00000405885	ENSP00000384406
ENST00000437654	ENSP00000405655
ENST00000458069	ENSP00000396318
ENST00000439555	ENSP00000392455
ENST00000472045
ENST00000459982
ENST00000463784
ENST00000476613	ENSP00000473661
ENST00000493208
ENST00000613424	ENSP00000480887

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 206 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Experimentally validated
Total	206 [view]
Protein-Protein	70 [view]
Protein-DNA	135 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0002819	regulation of adaptive immune response
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0007050	cell cycle arrest
GO:0007596	blood coagulation
GO:0008285	negative regulation of cell proliferation
GO:0010468	regulation of gene expression
GO:0019221	cytokine-mediated signaling pathway
GO:0032481	positive regulation of type I interferon production
GO:0032728	positive regulation of interferon-beta production
GO:0034124	regulation of MyD88-dependent toll-like receptor signaling pathway
GO:0035458	cellular response to interferon-beta
GO:0043374	CD8-positive, alpha-beta T cell differentiation
GO:0045084	positive regulation of interleukin-12 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045088	regulation of innate immune response
GO:0045590	negative regulation of regulatory T cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051607	defense response to virus
GO:0051726	regulation of cell cycle
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway
GO:0071260	cellular response to mechanical stimulus
GO:2000564	regulation of CD8-positive, alpha-beta T cell proliferation