Version 5.4
| Homo sapiens Gene: NFKBIZ | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-48252.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | NFKBIZ | ||||||||||||||||||||||
| Gene Name | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | ||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||||||
| Ensembl Gene | ENSG00000144802 | ||||||||||||||||||||||
| Encoded Proteins |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||
| Summary |
Inhibits the DNA binding of RELA and NFKB1
A key regulator of IL-6 production in human monocytes and plays an important role in both TLR and NOD-like receptor ligand induced inflammation
IFNG interferes with the IL-1/NFKBIZ axis in β-glucan-activated dendritic cells and promotes T cell-mediated immune responses with increased release of IFNG and IL22, and diminished production of IL17A.
TET2 selectively mediates active repression of IL6 transcription via NFKBIZ and HDAC2 during inflammation resolution in innate myeloid cells, including dendritic cells and macrophages.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||||||
| Summary |
[Mus musculus] Tet2 selectively mediates active repression of Il6 transcription via Nfkbiz and Hdac2 during inflammation resolution in innate myeloid cells, including dendritic cells and macrophages.
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| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 3:101827991-101861022 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | q12.3 | ||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH |
TNFalpha pathway
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| REACTOME | |||||||||||||||||||||||
| KEGG | |||||||||||||||||||||||
| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| UniGene | Hs.319171 Hs.706101 | ||||||||||||||||||||||
| RefSeq | NM_001005474 NM_031419 | ||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS2946 CCDS43123 | ||||||||||||||||||||||
| HPRD | 09217 | ||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||