Homo sapiens Gene: NFKBIZ
Summary
InnateDB Gene IDBG-48252.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFKBIZ
Gene Name nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000144802
Encoded Proteins
IDBP-48254
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
IDBP-48256
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
IDBP-242371
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
IDBP-475260
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
IDBP-479075
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
IDBP-482699
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
IDBP-473746
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 16513645
Inhibits the DNA binding of RELA and NFKB1
PMID 19783680
A key regulator of IL-6 production in human monocytes and plays an important role in both TLR and NOD-like receptor ligand induced inflammation
PMID 25474109
IFNG interferes with the IL-1/NFKBIZ axis in β-glucan-activated dendritic cells and promotes T cell-mediated immune responses with increased release of IFNG and IL22, and diminished production of IL17A.
PMID 26287468
TET2 selectively mediates active repression of IL6 transcription via NFKBIZ and HDAC2 during inflammation resolution in innate myeloid cells, including dendritic cells and macrophages.
InnateDB Annotation from Orthologs
Summary
PMID 26287468
[Mus musculus] Tet2 selectively mediates active repression of Il6 transcription via Nfkbiz and Hdac2 during inflammation resolution in innate myeloid cells, including dendritic cells and macrophages.
Entrez Gene
Summary This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:101827991-101861022
Strand Forward strand
Band q12.3
Transcripts
ENST00000326151 ENSP00000325593
ENST00000326172 ENSP00000325663
ENST00000394054 ENSP00000377618
ENST00000461724 ENSP00000418502
ENST00000483180 ENSP00000419800
ENST00000486444
ENST00000491281 ENSP00000418498
ENST00000465476
ENST00000477601 ENSP00000420700
ENST00000495089
ENST00000495719
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 7 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006954 inflammatory response
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000035356
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000010987
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9BYH8
TrEMBL C9J5G8 C9J5I7 C9JZ23
UniProt Splice Variant
Entrez Gene 64332
UniGene Hs.319171 Hs.706101
RefSeq NM_001005474 NM_031419
HUGO HGNC:29805
OMIM 608004
CCDS CCDS2946 CCDS43123
HPRD
IMGT
EMBL AB037925 AC020651 AF548362 AK054787 AK091782 BC060800 CH471052 DQ224339
GenPept AAH60800 AAN40698 ABB02425 BAB40337 BAC03746 BAG51424 EAW79771 EAW79772
RNA Seq Atlas 64332

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca