Homo sapiens Gene: MED14
Summary
InnateDB Gene IDBG-57018.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MED14
Gene Name mediator complex subunit 14
Synonyms CRSP150; CRSP2; CSRP; CXorf4; DRIP150; EXLM1; RGR1; TRAP170
Species Homo sapiens
Ensembl Gene ENSG00000180182
Encoded Proteins
mediator complex subunit 14
mediator complex subunit 14
mediator complex subunit 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:40648306-40735858
Strand Reverse strand
Band p11.4
Transcripts
ENST00000324817 ENSP00000323720
ENST00000416199 ENSP00000392586
ENST00000433003 ENSP00000411357
ENST00000472736
ENST00000496531
ENST00000482034
ENST00000492219
ENST00000495865
ENST00000463072
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 88 [view]
Protein-Protein 6 [view]
Protein-DNA 82 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0003712 transcription cofactor activity
GO:0003713 transcription coactivator activity
GO:0004872 receptor activity
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0042809 vitamin D receptor binding
GO:0046966 thyroid hormone receptor binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0010467 gene expression
GO:0019827 stem cell maintenance
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030521 androgen receptor signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016020 membrane
GO:0016592 mediator complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Metabolism of lipids and lipoproteins pathway
PPARA activates gene expression pathway
Generic Transcription Pathway pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Transcriptional regulation of white adipocyte differentiation pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O60244
TrEMBL H7C017 H7C3E5
UniProt Splice Variant
Entrez Gene 9282
UniGene Hs.407604 Hs.602565 Hs.609904
RefSeq NM_004229 XM_005272699 XM_005272701
HUGO HGNC:2370
OMIM 300182
CCDS CCDS14254
HPRD 02172
IMGT
EMBL AB006651 AB006652 AC092474 AC093029 AF104256 AF135802 AF304448 BC098377 BC132672 BC132674
GenPept AAD12725 AAD24360 AAG22547 AAH98377 AAI32673 AAI32675 BAA28626 BAA28627
RNA Seq Atlas 9282