Homo sapiens Gene: MAP3K11
Summary
InnateDB Gene IDBG-57450.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP3K11
Gene Name mitogen-activated protein kinase kinase kinase 11
Synonyms MEKK11; MLK-3; MLK3; PTK1; SPRK;
Species Homo sapiens
Ensembl Gene ENSG00000173327
Encoded Proteins
mitogen-activated protein kinase kinase kinase 11
mitogen-activated protein kinase kinase kinase 11
mitogen-activated protein kinase kinase kinase 11
mitogen-activated protein kinase kinase kinase 11
mitogen-activated protein kinase kinase kinase 11
mitogen-activated protein kinase kinase kinase 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:65597755-65615382
Strand Reverse strand
Band q13.1
Transcripts
ENST00000309100 ENSP00000309597
ENST00000532507 ENSP00000432068
ENST00000530153 ENSP00000433886
ENST00000524848 ENSP00000431506
ENST00000534432
ENST00000526647
ENST00000524856
ENST00000533032
ENST00000530949
ENST00000526293 ENSP00000435970
ENST00000529839 ENSP00000435237
ENST00000534110
ENST00000527304
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 55 [view]
Protein-Protein 52 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004706 JUN kinase kinase kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0048365 Rac GTPase binding
Biological Process
GO:0000080 mitotic G1 phase
GO:0000187 activation of MAPK activity
GO:0006468 protein phosphorylation
GO:0007017 microtubule-based process
GO:0007254 JNK cascade
GO:0007256 activation of JNKK activity
GO:0007257 activation of JUN kinase activity
GO:0008219 cell death
GO:0008283 cell proliferation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0043065 positive regulation of apoptotic process
GO:0043507 positive regulation of JUN kinase activity
GO:0043525 positive regulation of neuron apoptotic process
GO:0046330 positive regulation of JNK cascade
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005874 microtubule
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
REACTOME
KEGG
MAPK signaling pathway pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Mapkinase signaling pathway [Biocarta view]
PID NCI
Reelin signaling pathway
RAC1 signaling pathway
CDC42 signaling events
IFN-gamma pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.502872 Hs.714680
RefSeq NM_002419
HUGO
OMIM
CCDS CCDS8107
HPRD 02502
IMGT
EMBL
GenPept
RNA Seq Atlas