InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAP3K11

Summary

InnateDB Gene

IDBG-57450.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP3K11

Gene Name

mitogen-activated protein kinase kinase kinase 11

Synonyms

MEKK11; MLK-3; MLK3; PTK1; SPRK

Species

Homo sapiens

Ensembl Gene

ENSG00000173327

Encoded Proteins

IDBP-57452

mitogen-activated protein kinase kinase kinase 11

IDBP-593453

mitogen-activated protein kinase kinase kinase 11

IDBP-591138

mitogen-activated protein kinase kinase kinase 11

IDBP-602559

mitogen-activated protein kinase kinase kinase 11

IDBP-595703

mitogen-activated protein kinase kinase kinase 11

IDBP-601838

mitogen-activated protein kinase kinase kinase 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:65597755-65615382

Strand

Reverse strand

Band

q13.1

Transcripts

ENST00000309100	ENSP00000309597
ENST00000532507	ENSP00000432068
ENST00000530153	ENSP00000433886
ENST00000524848	ENSP00000431506
ENST00000534432
ENST00000526647
ENST00000524856
ENST00000533032
ENST00000530949
ENST00000526293	ENSP00000435970
ENST00000529839	ENSP00000435237
ENST00000534110
ENST00000527304

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	55 [view]
Protein-Protein	52 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004706	JUN kinase kinase kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0048365	Rac GTPase binding

Biological Process

GO:0000080	mitotic G1 phase
GO:0000187	activation of MAPK activity
GO:0006468	protein phosphorylation
GO:0007017	microtubule-based process
GO:0007254	JNK cascade
GO:0007256	activation of JNKK activity
GO:0007257	activation of JUN kinase activity
GO:0008219	cell death
GO:0008283	cell proliferation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0043065	positive regulation of apoptotic process
GO:0043507	positive regulation of JUN kinase activity
GO:0043525	positive regulation of neuron apoptotic process
GO:0046330	positive regulation of JNK cascade
GO:0046777	protein autophosphorylation