Version 5.4
| Bos taurus Gene: IKBKB | |||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-629838.3 | ||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||
| Gene Symbol | IKBKB | ||||||||||||||||||||||||||||||||
| Gene Name | Inhibitor of nuclear factor kappa-B kinase subunit beta | ||||||||||||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000007599 | ||||||||||||||||||||||||||||||||
| Encoded Proteins |
Inhibitor of nuclear factor kappa-B kinase subunit beta
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||
| Summary |
[Homo sapiens] IKBKB regulates late-phase allergic reactions promoted by the release of pro-inflammatory cytokines in an NF-kappaB-dependent manner.
[Homo sapiens] Phosphorylated IKBKB is conjugated with a monoubiquitin by the E3 ubiquitin ligase TRIM21 leading to down-regulatioin of IKBKB-induced NF-kappaB signalling. The TRIM21-mediated monoubiquitination is involved in the translocation of active IKBKB to autophagosomes.
[Homo sapiens] IKBKB and other IKK kinases regulate each other by an intricate network involving phosphorylation of their catalytic and regulatory (NEMO, TANK) subunits to balance their activities during innate immunity.
[Homo sapiens] GNB2L1 (RACK1) negatively regulates NFκB activation by interacting with CHUK and IKBKB. The interaction interferes with the recruitment of the IKK complex to TRAF2 .
[Homo sapiens] The reversible ubiquitin editing of NLRC5 determines NLRC5â?? IKBKB interaction dynamics and plays a crucial role in precisely regulating NFκB signalling
[Homo sapiens] Enterovirus 71 2C protein binds to RELA and IKBKB to inhibit NF-kB activation and evade innate immune defenses.
[Mus musculus] Ikbkb and other IKK kinases regulate each other by an intricate network involving phosphorylation of their catalytic and regulatory (NEMO, TANK) subunits to balance their activities during innate immunity.
[Mus musculus] The reversible ubiquitin editing of Nlrc5 determines Nlrc5â?? Ikbkb interaction dynamics and plays a crucial role in precisely regulating NFκB signalling
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| Entrez Gene | |||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104365:
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011] |
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| Gene Information | |||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 27:36813226-36865778 | ||||||||||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||||||||||
| Band | |||||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 190 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||
| REACTOME |
NOD1/2 Signaling Pathway pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Activated TLR4 signalling pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88-independent cascade pathway
Cytosolic sensors of pathogen-associated DNA pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
IKK complex recruitment mediated by RIP1 pathway
Cytokine Signaling in Immune system pathway
Downstream TCR signaling pathway
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Toll-Like Receptors Cascades pathway
Signal Transduction pathway
TRAF6 mediated NF-kB activation pathway
NF-kB is activated and signals survival pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
p75NTR recruits signalling complexes pathway
Signalling by NGF pathway
FCERI mediated NF-kB activation pathway
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
Adaptive Immune System pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Activation of NF-kappaB in B cells pathway
MyD88 dependent cascade initiated on endosome pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
p75 NTR receptor-mediated signalling pathway
Innate Immune System pathway
Interleukin-1 signaling pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
RIP-mediated NFkB activation via ZBP1 pathway
Signaling by Interleukins pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
IRAK1 recruits IKK complex pathway
MyD88 cascade initiated on plasma membrane pathway
TCR signaling pathway
p75NTR signals via NF-kB pathway
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| KEGG | |||||||||||||||||||||||||||||||||
| INOH | |||||||||||||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||
| NETPATH |
TGF_beta_Receptor pathway
TNFalpha pathway
TCR pathway
BCR pathway
IL1 pathway
IL4 pathway
RANKL pathway
Leptin pathway
TSH pathway
TWEAK pathway
IL11 pathway
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| REACTOME |
RIP-mediated NFkB activation via ZBP1 pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
TRAF6 mediated NF-kB activation pathway
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
IKK complex recruitment mediated by RIP1 pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
IRAK1 recruits IKK complex pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
NOD1/2 Signaling Pathway pathway
Downstream TCR signaling pathway
Interleukin-1 signaling pathway
Activation of NF-kappaB in B cells pathway
p75NTR recruits signalling complexes pathway
NF-kB is activated and signals survival pathway
FCERI mediated NF-kB activation pathway
Signalling by NGF pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
TCR signaling pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Fc epsilon receptor (FCERI) signaling pathway
p75 NTR receptor-mediated signalling pathway
p75NTR signals via NF-kB pathway
Signal Transduction pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Adaptive Immune System pathway
Immune System pathway
Signaling by Interleukins pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Cytosolic sensors of pathogen-associated DNA pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
TRAF6 mediated NF-kB activation pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream TCR signaling pathway
MyD88 cascade initiated on plasma membrane pathway
FCERI mediated NF-kB activation pathway
Cytokine Signaling in Immune system pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Activation of NF-kappaB in B cells pathway
p75NTR recruits signalling complexes pathway
Fc epsilon receptor (FCERI) signaling pathway
Toll-Like Receptors Cascades pathway
Signaling by Interleukins pathway
NOD1/2 Signaling Pathway pathway
p75NTR signals via NF-kB pathway
MyD88 dependent cascade initiated on endosome pathway
Cytosolic sensors of pathogen-associated DNA pathway
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway
Signalling by NGF pathway
RIP-mediated NFkB activation via ZBP1 pathway
Adaptive Immune System pathway
NF-kB is activated and signals survival pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Activated TLR4 signalling pathway
IKK complex recruitment mediated by RIP1 pathway
Interleukin-1 signaling pathway
MyD88-independent cascade pathway
Signal Transduction pathway
p75 NTR receptor-mediated signalling pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
TCR signaling pathway
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
IRAK1 recruits IKK complex pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG |
mTOR signaling pathway pathway
Acute myeloid leukemia pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Apoptosis pathway
MAPK signaling pathway pathway
Small cell lung cancer pathway
Insulin signaling pathway pathway
B cell receptor signaling pathway pathway
Prostate cancer pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Type II diabetes mellitus pathway
Chronic myeloid leukemia pathway
Adipocytokine signaling pathway pathway
Pancreatic cancer pathway
Neurotrophin signaling pathway pathway
Chemokine signaling pathway pathway
Pathways in cancer pathway
RIG-I-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
Chagas disease (American trypanosomiasis) pathway
Osteoclast differentiation pathway
Shigellosis pathway
Toxoplasmosis pathway
Hepatitis C pathway
Type II diabetes mellitus pathway
Insulin signaling pathway pathway
Acute myeloid leukemia pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
MAPK signaling pathway pathway
mTOR signaling pathway pathway
Small cell lung cancer pathway
Adipocytokine signaling pathway pathway
Apoptosis pathway
Prostate cancer pathway
Chronic myeloid leukemia pathway
B cell receptor signaling pathway pathway
Pancreatic cancer pathway
Chemokine signaling pathway pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
RIG-I-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
Osteoclast differentiation pathway
Toxoplasmosis pathway
Hepatitis C pathway
Chagas disease (American trypanosomiasis) pathway
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| INOH |
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
TNFR1 signaling pathway pathway
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
TNFR1 signaling pathway pathway
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| PID NCI |
Atypical NF-kappaB pathway
TCR signaling in naïve CD8+ T cells
TCR signaling in naïve CD4+ T cells
IL1-mediated signaling events
TNF receptor signaling pathway
TRAIL signaling pathway
mTOR signaling pathway
FoxO family signaling
p75(NTR)-mediated signaling
BCR signaling pathway
Canonical NF-kappaB pathway
GMCSF-mediated signaling events
Validated transcriptional targets of TAp63 isoforms
Fc-epsilon receptor I signaling in mast cells
Endogenous TLR signaling
FAS (CD95) signaling pathway
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| Cross-References | |||||||||||||||||||||||||||||||||
| SwissProt | Q95KV0 | ||||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||
| Entrez Gene | 281854 | ||||||||||||||||||||||||||||||||
| UniGene | Bt.9023 | ||||||||||||||||||||||||||||||||
| RefSeq | NM_174353 | ||||||||||||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||
| EMBL | AJ414556 BT021585 | ||||||||||||||||||||||||||||||||
| GenPept | AAX46432 CAC93687 | ||||||||||||||||||||||||||||||||
| RNA Seq Atlas | 281854 | ||||||||||||||||||||||||||||||||