Version 5.4
Bos taurus Gene: ITGB1
Summary
InnateDB Gene IDBG-637396.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGB1
Gene Name Integrin beta-1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015910
Encoded Proteins
IDBP-689427
Integrin beta-1
IDBP-689431
Integrin beta-1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20877569
[Homo sapiens] ITGB1 along with ITGA3 is a novel regulator for the recognition of bacterial lipopeptides. ITGB1/ITGA3 integrin regulates endosomal Toll-like receptor (TLR)-2/TLR1 signalling, serving as a mechanism for modulating inflammatory responses.
PMID 26288256
[Homo sapiens] IFNG primes mast cells for enhanced anti-bacterial and pro-inflammatory responses to Staphylococcus aureus, partially mediated by ITGB1.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150093:
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:20248945-20292114
Strand Forward strand
Band
Transcripts
ENSBTAT00000056716 ENSBTAP00000052015
ENSBTAT00000021156 ENSBTAP00000021156
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 101 interaction(s) predicted by orthology.
Predicted by orthology
Total 101 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0003779 actin binding
GO:0004872 receptor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0043236 laminin binding
GO:0046872 metal ion binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001701 in utero embryonic development
GO:0001708 cell fate specification
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0007155 cell adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007161 calcium-independent cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007275 multicellular organismal development
GO:0008284 positive regulation of cell proliferation
GO:0008354 germ cell migration
GO:0009615 response to virus
GO:0016032 viral process
GO:0016477 cell migration
GO:0021943 formation of radial glial scaffolds
GO:0031175 neuron projection development
GO:0031589 cell-substrate adhesion
GO:0033631 cell-cell adhesion mediated by integrin
GO:0043065 positive regulation of apoptotic process
GO:0045214 sarcomere organization
GO:0045596 negative regulation of cell differentiation
GO:0048675 axon extension
GO:0048738 cardiac muscle tissue development
GO:0051726 regulation of cell cycle
GO:0055007 cardiac muscle cell differentiation
GO:2000811 negative regulation of anoikis
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0030175 filopodium
GO:0031594 neuromuscular junction
GO:0032587 ruffle membrane
GO:0034677 integrin alpha7-beta1 complex
GO:0035748 myelin sheath abaxonal region
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0042995 cell projection
GO:0043235 receptor complex
GO:0045121 membrane raft
GO:0045202 synapse
GO:0055037 recycling endosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000150093
View Gene Order
ENSMUSG00000025809
View Gene Order
Pathways
NETPATH
REACTOME
REACT_208597
Cell surface interactions at the vascular wall pathway
REACT_219927
Non-integrin membrane-ECM interactions pathway
REACT_212274
Fibronectin matrix formation pathway
REACT_206044
Laminin interactions pathway
REACT_223425
Extracellular matrix organization pathway
REACT_215526
L1CAM interactions pathway
REACT_211113
Basigin interactions pathway
REACT_216694
Localization of the PINCH-ILK-PARVIN complex to focal adhesions pathway
REACT_212196
Hemostasis pathway
REACT_213138
Immune System pathway
REACT_213693
Molecules associated with elastic fibres pathway
REACT_216684
Signal transduction by L1 pathway
REACT_214866
Cell junction organization pathway
REACT_209223
Elastic fibre formation pathway
REACT_206475
Cell-Cell communication pathway
REACT_203140
Axon guidance pathway
REACT_207047
Integrin cell surface interactions pathway
REACT_220688
Platelet Adhesion to exposed collagen pathway
REACT_214880
CHL1 interactions pathway
REACT_214469
Adaptive Immune System pathway
REACT_213279
Cell-extracellular matrix interactions pathway
REACT_222217
ECM proteoglycans pathway
REACT_214741
Other semaphorin interactions pathway
REACT_204848
Syndecan interactions pathway
REACT_215390
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_221457
Semaphorin interactions pathway
REACT_220844
Developmental Biology pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_12560
Basigin interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_1230
Platelet Adhesion to exposed collagen pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_160131
Fibronectin matrix formation pathway
REACT_20617
Localization of the PINCH-ILK-PARVIN complex to focal adhesions pathway
REACT_20649
Cell-extracellular matrix interactions pathway
REACT_22272
Signal transduction by L1 pathway
REACT_22292
CHL1 interactions pathway
REACT_22205
L1CAM interactions pathway
REACT_19200
Other semaphorin interactions pathway
REACT_111045
Developmental Biology pathway
REACT_111155
Cell-Cell communication pathway
REACT_118779
Extracellular matrix organization pathway
REACT_19271
Semaphorin interactions pathway
REACT_20676
Cell junction organization pathway
REACT_163942
Syndecan interactions pathway
REACT_18266
Axon guidance pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_163906
ECM proteoglycans pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
REACT_169262
Laminin interactions pathway
REACT_604
Hemostasis pathway
REACT_196644
Syndecan interactions pathway
REACT_224553
Hemostasis pathway
REACT_204211
Fibronectin matrix formation pathway
REACT_198996
Elastic fibre formation pathway
REACT_198998
Molecules associated with elastic fibres pathway
REACT_202937
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_230745
Immune System pathway
REACT_206066
Extracellular matrix organization pathway
REACT_211508
Basigin interactions pathway
REACT_202342
Laminin interactions pathway
REACT_225107
Platelet Adhesion to exposed collagen pathway
REACT_198267
CHL1 interactions pathway
REACT_261444
Axon guidance pathway
REACT_216309
Integrin cell surface interactions pathway
REACT_243772
Cell-extracellular matrix interactions pathway
REACT_215461
Signal transduction by L1 pathway
REACT_219680
L1CAM interactions pathway
REACT_242946
Localization of the PINCH-ILK-PARVIN complex to focal adhesions pathway
REACT_229531
Adaptive Immune System pathway
REACT_188576
Developmental Biology pathway
REACT_196606
ECM proteoglycans pathway
REACT_196607
Non-integrin membrane-ECM interactions pathway
REACT_263034
Semaphorin interactions pathway
REACT_241978
Cell junction organization pathway
REACT_231928
Other semaphorin interactions pathway
REACT_223082
Cell-Cell communication pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04512
ECM-receptor interaction pathway
hsa04360
Axon guidance pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa05222
Small cell lung cancer pathway
hsa04510
Focal adhesion pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05200
Pathways in cancer pathway
hsa05414
Dilated cardiomyopathy pathway
hsa05140
Leishmaniasis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05131
Shigellosis pathway
hsa05145
Toxoplasmosis pathway
hsa04145
Phagosome pathway
mmu04360
Axon guidance pathway
mmu04514
Cell adhesion molecules (CAMs) pathway
mmu04512
ECM-receptor interaction pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu05222
Small cell lung cancer pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu04510
Focal adhesion pathway
mmu05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
mmu05200
Pathways in cancer pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
mmu05140
Leishmaniasis pathway
mmu04145
Phagosome pathway
mmu05145
Toxoplasmosis pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
INOH website
Integrin signaling pathway pathway
INOH website
Integrin signaling pathway pathway
PID NCI
syndecan_2_pathway
Syndecan-2-mediated signaling events
integrin1_pathway
Beta1 integrin cell surface interactions
reelinpathway
Reelin signaling pathway
integrin_cs_pathway
Integrin family cell surface interactions
lymphangiogenesis_pathway
VEGFR3 signaling in lymphatic endothelium
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
integrin_a9b1_pathway
Alpha9 beta1 integrin signaling events
a6b1_a6b4_integrin_pathway
a6b1 and a6b4 Integrin signaling
fak_pathway
Signaling events mediated by focal adhesion kinase
myc_represspathway
Validated targets of C-MYC transcriptional repression
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
tcptp_pathway
Signaling events mediated by TCPTP
prlsignalingeventspathway
Signaling events mediated by PRL
syndecan_4_pathway
Syndecan-4-mediated signaling events
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
rhoa_pathway
RhoA signaling pathway
a4b7_pathway
a4b7 Integrin signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.9973
RefSeq NM_174368 XM_005214148
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca