Version 5.4
| Bos taurus Gene: IRF3 | |||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-640634.3 | ||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||
| Gene Symbol | IRF3 | ||||||||||||||||||||||||||||||||||
| Gene Name | Interferon regulatory factor 3 | ||||||||||||||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000006633 | ||||||||||||||||||||||||||||||||||
| Encoded Proteins |
Interferon regulatory factor 3
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| Protein Structure | |||||||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||
| Summary |
[Homo sapiens] IRF3 is a transcription factor that activates type-1 interferon (IFN) and IFN responsive genes.
[Homo sapiens] IRF3 is directly activated after virus infection and functions as a key activator of the intermediate/early alpha/beta interferon (IFN) genes as well as the RANTES chemokine gene.
[Homo sapiens] IRF3 transcription factor induces type I interferons (IFNs) and elicits innate antiviral response. TMEM173 (MITA) is a critical mediator of virus-triggered IRF3 activation and IFN expression.
[Homo sapiens] IRF3 phosphorylation is virus-inducible and results in IRF3 alteration of protein conformation to permit nuclear translocation, association with transcriptional partners, and primary activation of interferon (IFN)- and IFN-responsive genes.
[Homo sapiens] IRF3 is strongly phosphorylated at the late stages of a Sindbis virus infection to mount antiviral responses in human embryonic kidney cells.
[Homo sapiens] IRF3 is involved in the innate immune recognition of Plasmodium falciparum AT-rich DNA and in the subsequent induction of type I IFNs. Mice lacking Irf3/Irf7 are resistant to otherwise lethal cerebral malaria. (Demonstrated in mouse)
[Homo sapiens] IRF3 suppresses neuroinflammation through regulation of immunomodulatory MIR155 microRNA expression in astrocytes.
[Homo sapiens] HIV accessory protein Vpu targets IRF3 to endolysosome for proteolytic degradation to avoid antiviral immune responses.
[Homo sapiens] During the transcriptional response to Sendai virus infection, POLR2F(RNA Pol II) is recruited by IRF3 and NFκB to control virus induced gene activation.
[Homo sapiens] Vpu, an accessory protein encoded by HIV-1, contributes to the attenuation of the anti-viral response by partial inactivation of IRF3 while host cells undergo apoptosis.
[Homo sapiens] Hepatitis B virus (HBV) polymerase inhibits TMEM173-stimulated IRF3 activation and IFNB1 induction.
[Homo sapiens] Stimulation of TMEM173-dependent IRF3 activation by ultraviolet radiation is due to apoptotic signalling-dependent disruption of ULK1, a pro-autophagic protein that negatively regulates TMEM173.
[Homo sapiens] PQBP1 directly binds to reverse-transcribed HIV-1 DNA and interacts with MB21D1 to initiate an IRF3-dependent innate response
[Homo sapiens] 4-(2-chloro-6-fluorobenzyl)-N-(furan-2-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (G10) requires STING to trigger IRF3/IFN-associated transcription in human fibroblasts and subsequently blocking replication of Chikungunya virus, Venezuelan Encephalitis virus, and Sindbis virus.
[Homo sapiens] Influenza B virus induces IRF3 activation and IL29 (IFNL1) gene expression without a requirement for viral protein synthesis or replication and DDX58 is the critical pattern recognition receptor needed for IRF3 activation.
[Mus musculus] Irf3 is strongly phosphorylated at the late stages of a Sindbis virus infection to mount antiviral responses in human embryonic kidney cells. (Demonstrated in human)
[Mus musculus] Irf3 is involved in the innate immune recognition of Plasmodium falciparum AT-rich DNA and in the subsequent induction of type I IFNs. Mice lacking Irf3/Irf7 are resistant to otherwise lethal cerebral malaria.
[Mus musculus] Irf3 suppresses neuroinflammation through regulation of immunomodulatory mmu-mir-155 microRNA expression in astrocytes. (Demonstrated in human)
[Mus musculus] HIV accessory protein Vpu targets Irf3 to endolysosome for proteolytic degradation to avoid antiviral immune responses. (Demonstrated in human)
[Mus musculus] Endoplasmic reticulum stress primes macrophages to respond to innate immunity stimuli by activating IRF3.
[Mus musculus] Plasmodium RNA is a pathogen-associated molecular pattern (PAMP) capable of activating a type I IFN response via the cytosolic pattern recognition receptors Ifih1 and Mavs, as well as via transcription factors Irf3 and Irf7.
[Mus musculus] Il28ra (Ifnlr1), Stat1 and Irf3 are required for antibiotics to prevent persistent murine norovirus infection.
[Mus musculus] The innate immune system plays a role in immunogenic tumour recognition. Tumor-cell-derived DNA triggers Ifnb1 production and dendritic cell activation via Tmem173 and Irf3 cytosolic DNA sensing pathways.
[Mus musculus] Aberrant mitochondrial DNA (mtDNA) packaging promotes escape of mtDNA into the cytosol, where it engages the DNA sensor Mb21d1 and promotes Tmem173-Irf3-dependent signalling to elevate IFN-stimulated gene expression, potentiate type I IFN responses and confer broad viral resistance.
[Mus musculus] Ppp4c, a serine/threonine phosphatase, directly binds to Tbk1 upon virus infection to dephosphorylate Tbk1 and inhibit Tbk1 activation, and subsequently restrain Irf3 activation, resulting in suppressed production of type I IFN and IFN-stimulated genes.
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| Entrez Gene | |||||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126456:
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] |
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| Gene Information | |||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 18:56517723-56523302 | ||||||||||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||||||||||
| Band | |||||||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 83 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||
| REACTOME |
STING mediated induction of host immune responses pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Factors involved in megakaryocyte development and platelet production pathway
ISG15 antiviral mechanism pathway
Activated TLR4 signalling pathway
MyD88-independent cascade pathway
Cytosolic sensors of pathogen-associated DNA pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Cytokine Signaling in Immune system pathway
Hemostasis pathway
Immune System pathway
Antiviral mechanism by IFN-stimulated genes pathway
IRF3-mediated induction of type I IFN pathway
IRF3 mediated activation of type 1 IFN pathway
Toll-Like Receptors Cascades pathway
Negative regulators of RIG-I/MDA5 signaling pathway
TRAF3-dependent IRF activation pathway pathway
Interferon Signaling pathway
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production pathway
TRAF6 mediated IRF7 activation pathway
Innate Immune System pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG | |||||||||||||||||||||||||||||||||||
| INOH | |||||||||||||||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||
| REACTOME |
IRF3 mediated activation of type 1 IFN pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
STING mediated induction of host immune responses pathway
TRAF6 mediated IRF7 activation pathway
Negative regulators of RIG-I/MDA5 signaling pathway
TRAF3-dependent IRF activation pathway pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Interferon alpha/beta signaling pathway
ISG15 antiviral mechanism pathway
Interferon gamma signaling pathway
Factors involved in megakaryocyte development and platelet production pathway
IRF3-mediated induction of type I IFN pathway
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production pathway
Antiviral mechanism by IFN-stimulated genes pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Interferon Signaling pathway
Regulation of innate immune responses to cytosolic DNA pathway
Immune System pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Cytosolic sensors of pathogen-associated DNA pathway
Hemostasis pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Innate Immune System pathway
Hemostasis pathway
Cytokine Signaling in Immune system pathway
IRF3 mediated activation of type 1 IFN pathway
Antiviral mechanism by IFN-stimulated genes pathway
Negative regulators of RIG-I/MDA5 signaling pathway
ISG15 antiviral mechanism pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
Immune System pathway
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production pathway
TRAF6 mediated IRF7 activation pathway
Factors involved in megakaryocyte development and platelet production pathway
Interferon gamma signaling pathway
Interferon Signaling pathway
IRF3-mediated induction of type I IFN pathway
Toll-Like Receptors Cascades pathway
Cytosolic sensors of pathogen-associated DNA pathway
STING mediated induction of host immune responses pathway
Regulation of innate immune responses to cytosolic DNA pathway
Activated TLR4 signalling pathway
MyD88-independent cascade pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
TRIF-mediated TLR3/TLR4 signaling pathway
TRAF3-dependent IRF activation pathway pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG |
Toll-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
Hepatitis C pathway
Toll-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
Hepatitis C pathway
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| INOH | |||||||||||||||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||
| UniGene | Bt.45332 | ||||||||||||||||||||||||||||||||||
| RefSeq | NM_001029845 | ||||||||||||||||||||||||||||||||||
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| OMIM | |||||||||||||||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||
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| EMBL | |||||||||||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||||||||||||||