Version 5.4
Bos taurus Gene: TET2
Summary
InnateDB Gene IDBG-640688.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TET2
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017682
Encoded Proteins
IDBP-692983
tet methylcytosine dioxygenase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 26287468
[Homo sapiens] TET2 selectively mediates active repression of IL6 transcription via NFKBIZ and HDAC2 during inflammation resolution in innate myeloid cells, including dendritic cells and macrophages.
PMID 26287468
[Mus musculus] Tet2 selectively mediates active repression of Il6 transcription via Nfkbiz and Hdac2 during inflammation resolution in innate myeloid cells, including dendritic cells and macrophages.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168769:
The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:21176966-21218829
Strand Reverse strand
Band
Transcripts
ENSBTAT00000023517 ENSBTAP00000023517
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008198 ferrous iron binding
GO:0008270 zinc ion binding
GO:0070579 methylcytosine dioxygenase activity
Biological Process
GO:0001822 kidney development
GO:0006211 5-methylcytosine catabolic process
GO:0006493 protein O-linked glycosylation
GO:0009791 post-embryonic development
GO:0030097 hemopoiesis
GO:0030099 myeloid cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0080111 DNA demethylation
GO:0080182 histone H3-K4 trimethylation
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000168769
View Gene Order
ENSMUSG00000040943
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_200682
TET1,2,3 and TDG demethylate DNA pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_71
Gene Expression pathway
REACT_205737
Epigenetic regulation of gene expression pathway
REACT_223022
TET1,2,3 and TDG demethylate DNA pathway
REACT_233572
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca