Version 5.4
Mus musculus Protein: Atp8b5
Summary
InnateDB Protein IDBP-140540.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atp8b5
Protein Name ATPase, class I, type 8B, member 5
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000100018
InnateDB Gene IDBG-140536 (Atp8b5)
Protein Structure
UniProt Annotation
Function P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May play a role in phospholid transport across membranes and in acrosome formation. {ECO:0000269PubMed:19657017}.
Subcellular Localization Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000269PubMed:19657017}; Multi-pass membrane protein {ECO:0000269PubMed:19657017}.
Disease Associations
Tissue Specificity Highly expressed in testis. {ECO:0000269PubMed:19657017}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004012 phospholipid-translocating ATPase activity
GO:0005524 ATP binding
GO:0005548 phospholipid transporter activity
GO:0019829 cation-transporting ATPase activity
GO:0046872 metal ion binding
Biological Process
GO:0006812 cation transport
GO:0007030 Golgi organization
GO:0008152 metabolic process
GO:0015914 phospholipid transport
GO:0045332 phospholipid translocation
Cellular Component
GO:0001669 acrosomal vesicle
GO:0002080 acrosomal membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2444287
InterPro IPR008250 P-type ATPase, A domain
PFAM PF00122
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A3FIN4
PhosphoSite PhosphoSite-A3FIN4
TrEMBL
UniProt Splice Variant
Entrez Gene 320571
UniGene Mm.74465
RefSeq
MGI ID
MGI Symbol Atp8b5
OMIM
CCDS
HPRD
IMGT
EMBL AK076708 AK078567 AL732504 EF377342
GenPept ABN48718 BAC36451 BAC37336 CAM16526 CAM16528

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca