InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hdac2

Summary

InnateDB Protein

IDBP-143982.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hdac2

Protein Name

histone deacetylase 2

Synonyms

D10Wsu179e; mRPD3; YAF1; Yy1bp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019911

InnateDB Gene

IDBG-143980 (Hdac2)

Protein Structure

UniProt Annotation

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA- replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A. {ECO:0000250, ECO:0000269PubMed:15226430, ECO:0000269PubMed:17707228, ECO:0000269PubMed:20071335}.

Subcellular Localization

Nucleus. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 94 experimentally validated interaction(s) in this database.
They are also associated with 354 interaction(s) predicted by orthology.

Experimentally validated
Total	94 [view]
Protein-Protein	82 [view]
Protein-DNA	11 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	354 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004407	histone deacetylase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019213	deacetylase activity
GO:0019899	enzyme binding
GO:0031072	heat shock protein binding
GO:0031490	chromatin DNA binding
GO:0031492	nucleosomal DNA binding
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558	protein deacetylase activity
GO:0035851	Krueppel-associated box domain binding
GO:0043565	sequence-specific DNA binding
GO:0044822	poly(A) RNA binding
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006344	maintenance of chromatin silencing
GO:0006351	transcription, DNA-templated
GO:0006476	protein deacetylation
GO:0008284	positive regulation of cell proliferation
GO:0009913	epidermal cell differentiation
GO:0010870	positive regulation of receptor biosynthetic process
GO:0010977	negative regulation of neuron projection development
GO:0016358	dendrite development
GO:0016568	chromatin modification
GO:0016575	histone deacetylation
GO:0021766	hippocampus development
GO:0030182	neuron differentiation
GO:0032922	circadian regulation of gene expression
GO:0034605	cellular response to heat
GO:0042220	response to cocaine
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042493	response to drug
GO:0042733	embryonic digit morphogenesis
GO:0043044	ATP-dependent chromatin remodeling
GO:0043066	negative regulation of apoptotic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045087	innate immune response (InnateDB)
GO:0045862	positive regulation of proteolysis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048714	positive regulation of oligodendrocyte differentiation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051896	regulation of protein kinase B signaling
GO:0055013	cardiac muscle cell development
GO:0060044	negative regulation of cardiac muscle cell proliferation
GO:0060297	regulation of sarcomere organization
GO:0060789	hair follicle placode formation
GO:0061029	eyelid development in camera-type eye
GO:0061198	fungiform papilla formation
GO:0070932	histone H3 deacetylation
GO:0070933	histone H4 deacetylation
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090311	regulation of protein deacetylation
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0000118	histone deacetylase complex
GO:0000785	chromatin
GO:0000790	nuclear chromatin
GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005657	replication fork
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0016580	Sin3 complex
GO:0016581	NuRD complex
GO:0017053	transcriptional repressor complex
GO:0035098	ESC/E(Z) complex
GO:0043234	protein complex