InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Traf3

Summary

InnateDB Protein

IDBP-172560.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Traf3

Protein Name

TNF receptor-associated factor 3

Synonyms

AI528849; amn; CAP-1; CD40bp; CRAF1; LAP1; T-BAM;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021706

InnateDB Gene

IDBG-172558 (Traf3)

Protein Structure

UniProt Annotation

Function

Regulates pathways leading to the activation of NF- kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa- B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. {ECO:0000269PubMed:16306936, ECO:0000269PubMed:16306937, ECO:0000269PubMed:17015635, ECO:0000269PubMed:17158868, ECO:0000269PubMed:18313334, ECO:0000269PubMed:18997792, ECO:0000269PubMed:18997794, ECO:0000269PubMed:19228877, ECO:0000269PubMed:19898473, ECO:0000269PubMed:8934568}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:19898473}. Endosome {ECO:0000269PubMed:19898473}. Note=Undergoes endocytosis together with TLR4 upon LPS signaling.

Disease Associations

Tissue Specificity

Detected in bone marrow macrophages and spleen B-cells (at protein level). In adult, highest in brain. Also found in kidney, heart, thymus, spleen, lung, muscle, testis and ovary. Not found in liver. {ECO:0000269PubMed:18997792, ECO:0000269PubMed:19898473, ECO:0000269PubMed:8660894}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 115 interaction(s) predicted by orthology.

Experimentally validated
Total	62 [view]
Protein-Protein	62 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	115 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0019901	protein kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0031996	thioesterase binding

Biological Process

GO:0001817	regulation of cytokine production
GO:0002224	toll-like receptor signaling pathway
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0008063	Toll signaling pathway
GO:0016567	protein ubiquitination
GO:0030162	regulation of proteolysis
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032648	regulation of interferon-beta production
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0042981	regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0050688	regulation of defense response to virus