InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp8b5

Summary

InnateDB Protein

IDBP-265602.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp8b5

Protein Name

ATPase, class I, type 8B, member 5

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103575

InnateDB Gene

IDBG-140536 (Atp8b5)

Protein Structure

UniProt Annotation

Function

P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May play a role in phospholid transport across membranes and in acrosome formation. {ECO:0000269PubMed:19657017}.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000269PubMed:19657017}; Multi-pass membrane protein {ECO:0000269PubMed:19657017}.

Disease Associations

Tissue Specificity

Highly expressed in testis. {ECO:0000269PubMed:19657017}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004012	phospholipid-translocating ATPase activity
GO:0005524	ATP binding
GO:0005548	phospholipid transporter activity
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0006812	cation transport
GO:0007030	Golgi organization
GO:0008152	metabolic process
GO:0015914	phospholipid transport
GO:0045332	phospholipid translocation

Cellular Component

GO:0001669	acrosomal vesicle
GO:0002080	acrosomal membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2444287

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR006539 Cation-transporting P-type ATPase, subfamily IV
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM

PF00122
PF00702
PF08282
PF13419

PRINTS

PR00119
PR00120

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A3FIN4