Version 5.4
Mus musculus Protein: Hdac2
Summary
InnateDB Protein IDBP-270731.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Hdac2
Protein Name histone deacetylase 2
Synonyms D10Wsu179e; mRPD3; YAF1; Yy1bp;
Species Mus musculus
Ensembl Protein ENSMUSP00000101149
InnateDB Gene IDBG-143980 (Hdac2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 94 experimentally validated interaction(s) in this database.
They are also associated with 354 interaction(s) predicted by orthology.
Experimentally validated
Total 94 [view]
Protein-Protein 82 [view]
Protein-DNA 11 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 354 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0031490 chromatin DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0016575 histone deacetylation
GO:0021766 hippocampus development
GO:0030182 neuron differentiation
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051896 regulation of protein kinase B signaling
GO:0055013 cardiac muscle cell development
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060297 regulation of sarcomere organization
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090311 regulation of protein deacetylation
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005657 replication fork
GO:0005667 transcription factor complex
GO:0017053 transcriptional repressor complex
Protein Structure and Domains
PDB ID MGI:1097691
InterPro IPR000286 Histone deacetylase superfamily
IPR003084 Histone deacetylase
IPR023801 Histone deacetylase domain
PFAM PF00850
PRINTS PR01270
PR01271
PIRSF PIRSF037913
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q8BQ10
UniProt Splice Variant
Entrez Gene 15182
UniGene Mm.408743
RefSeq
MGI ID
MGI Symbol Hdac2
OMIM
CCDS
HPRD
IMGT
EMBL AC165370 AK051753
GenPept BAC34755

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca