InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NLRC5

Summary

InnateDB Protein

IDBP-377641.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NLRC5

Protein Name

NLR family, CARD domain containing 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000389739

InnateDB Gene

IDBG-32729 (NLRC5)

Protein Structure

UniProt Annotation

Function

Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. {ECO:0000269PubMed:20061403, ECO:0000269PubMed:20434986}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:20061403, ECO:0000269PubMed:20434986}.

Disease Associations

Tissue Specificity

Expressed in spleen, thymus, lung, brain, tonsil, heart and prostate. {ECO:0000269PubMed:20061403, ECO:0000269PubMed:20434986}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032480	negative regulation of type I interferon production
GO:0043549	regulation of kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0045345	positive regulation of MHC class I biosynthetic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051607	defense response to virus
GO:0060335	positive regulation of interferon-gamma-mediated signaling pathway
GO:0060339	negative regulation of type I interferon-mediated signaling pathway
GO:0060340	positive regulation of type I interferon-mediated signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR001611 Leucine-rich repeat
IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR006553 Leucine-rich repeat, cysteine-containing subtype
IPR007111 NACHT nucleoside triphosphatase
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00560
PF13504
PF13855

PRINTS

PIRSF

SMART

SM00368
SM00367

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q86WI3