InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ikbkb

Summary

InnateDB Protein

IDBP-538905.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ikbkb

Protein Name

inhibitor of kappaB kinase beta

Synonyms

AI132552; IKK-2; IKK-beta; IKK[b]; IKK2; IKKbeta;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000120049

InnateDB Gene

IDBG-141021 (Ikbkb)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 169 interaction(s) predicted by orthology.

Experimentally validated
Total	75 [view]
Protein-Protein	72 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	169 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0008384	IkappaB kinase activity
GO:0097110	scaffold protein binding

Biological Process

GO:0001782	B cell homeostasis
GO:0007252	I-kappaB phosphorylation
GO:0010765	positive regulation of sodium ion transport
GO:0023014	signal transduction by phosphorylation
GO:0045087	innate immune response (InnateDB)
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:2001259	positive regulation of cation channel activity

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1338071

InterPro

IPR022007 I-kappa-kinase-beta NEMO binding domain

PFAM

PF12179

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

F6XPL0

UniProt Splice Variant

Entrez Gene

16150

UniGene

Mm.401349

RefSeq

MGI ID

MGI Symbol

Ikbkb

OMIM

CCDS

HPRD

IMGT

EMBL

AC121835

GenPept