Version 5.4
Mus musculus Protein: Irf1
Summary
InnateDB Protein IDBP-541656.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Irf1
Protein Name interferon regulatory factor 1
Synonyms AU020929; Irf-1;
Species Mus musculus
Ensembl Protein ENSMUSP00000114315
InnateDB Gene IDBG-172251 (Irf1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 120 interaction(s) predicted by orthology.
Experimentally validated
Total 83 [view]
Protein-Protein 22 [view]
Protein-DNA 61 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 120 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000975 regulatory region DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006915 apoptotic process
GO:0007050 cell cycle arrest
GO:0010468 regulation of gene expression
GO:0032728 positive regulation of interferon-beta production
GO:0035458 cellular response to interferon-beta
GO:0043374 CD8-positive, alpha-beta T cell differentiation
GO:0045084 positive regulation of interleukin-12 biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051607 defense response to virus
GO:0071260 cellular response to mechanical stimulus
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:96590
InterPro IPR001346 Interferon regulatory factor DNA-binding domain
PFAM PF00605
PRINTS PR00267
PIRSF
SMART SM00348
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q5SX16
UniProt Splice Variant
Entrez Gene 16362
UniGene Mm.399626
RefSeq
MGI ID
MGI Symbol Irf1
OMIM
CCDS
HPRD
IMGT
EMBL AL596182
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca