InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAP3K11

Summary

InnateDB Protein

IDBP-57452.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP3K11

Protein Name

mitogen-activated protein kinase kinase kinase 11

Synonyms

MEKK11; MLK-3; MLK3; PTK1; SPRK;

Species

Homo sapiens

Ensembl Protein

ENSP00000309597

InnateDB Gene

IDBG-57450 (MAP3K11)

Protein Structure

UniProt Annotation

Function

Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269PubMed:12529434, ECO:0000269PubMed:15258589, ECO:0000269PubMed:8195146, ECO:0000269PubMed:9003778}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:12529434}. Note=Location is cell cycle dependent.

Disease Associations

Tissue Specificity

Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain. {ECO:0000269PubMed:8183572, ECO:0000269PubMed:8195146}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	55 [view]
Protein-Protein	52 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004706	JUN kinase kinase kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0048365	Rac GTPase binding

Biological Process

GO:0000080	mitotic G1 phase
GO:0000187	activation of MAPK activity
GO:0006468	protein phosphorylation
GO:0007017	microtubule-based process
GO:0007254	JNK cascade
GO:0007256	activation of JNKK activity
GO:0007257	activation of JUN kinase activity
GO:0008219	cell death
GO:0008283	cell proliferation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0043065	positive regulation of apoptotic process
GO:0043507	positive regulation of JUN kinase activity
GO:0043525	positive regulation of neuron apoptotic process
GO:0046330	positive regulation of JNK cascade
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005874	microtubule
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR016231 Mitogen-activated protein (MAP) kinase kinase kinase, 9/10/11
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00018
PF14604
PF07653

PRINTS

PR00109
PR00452

PIRSF

PIRSF000556

SMART

SM00326
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References