InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Irf4

Summary

InnateDB Gene

IDBG-141793.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Irf4

Gene Name

interferon regulatory factor 4

Synonyms

AI385587; IRF-4; LSIRF; Spip

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021356

Encoded Proteins

IDBP-141795

interferon regulatory factor 4

IDBP-260549

interferon regulatory factor 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 12566414

[Homo sapiens] IRF4 participates in the regulation of lymphoid cell apoptosis by modulating the efficiency of the Fas-mediated death signal.

PMID 16272311

[Homo sapiens] IRF4 provides a positive feedback signal for its own gene expression in dendritic cells (DCs) and the expression of IRF4 mRNA, but not of other IRFs, is specifically up-regulated during DC differentiation.

PMID 24670424

[Homo sapiens] Following NOD2 activation, IRF4 interacts with MYD88, TRAF6, and RIPK2 and downregulates K63-linked polyubiquitinylation of RICK and TRAF6 leading to disruption of NFkB activation pathways.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137265:
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:30749226-30766927

Strand

Forward strand

Band

A3.2

Transcripts

ENSMUST00000021784	ENSMUSP00000021784
ENSMUST00000110307	ENSMUSP00000105936

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.

Experimentally validated
Total	69 [view]
Protein-Protein	15 [view]
Protein-DNA	54 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	60 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0016279	protein-lysine N-methyltransferase activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006479	protein methylation
GO:0018022	peptidyl-lysine methylation
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0042832	defense response to protozoan
GO:0043011	myeloid dendritic cell differentiation
GO:0043388	positive regulation of DNA binding
GO:0043966	histone H3 acetylation
GO:0043967	histone H4 acetylation
GO:0045082	positive regulation of interleukin-10 biosynthetic process
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045368	positive regulation of interleukin-13 biosynthetic process
GO:0045404	positive regulation of interleukin-4 biosynthetic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0072540	T-helper 17 cell lineage commitment