Version 5.4
| Mus musculus Gene: Nod1 | |||||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-149298.6 | ||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||
| Gene Symbol | Nod1 | ||||||||||||||||||||||||||||||||||||
| Gene Name | nucleotide-binding oligomerization domain containing 1 | ||||||||||||||||||||||||||||||||||||
| Synonyms | C230079P11; Card4; F830007N14Rik; Nlrc1 | ||||||||||||||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000038058 | ||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
nucleotide-binding oligomerization domain containing 1
nucleotide-binding oligomerization domain containing 1
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||||||||||||||||
| Summary |
Nod1 and Nod2 activation results in substantial secretion of Ccl5 by murine macrophages and induces binding of NF-kappaB subunits to Ccl5 promoter.
Nod1 can activate the ISGF3 signaling pathway that is usually associated with protection against viral infection to provide mice with robust type I IFN-mediated protection from H. pylori and possibly other mucosal infections.
Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila.
Nod1 and Nod2 can detect Legionella pneumophila and these receptors modulate the in vivo pulmonary immune response differently.
Nod1 is a peripheral peptidoglycan intracellular sensor and is important for the progression and pathogenesis of experimental autoimmune encephalomyelitis (animal model of multiple sclerosis).
Nod1 detects heat-killed Legionella pneumophila and stimulates NFkB and IFN-beta promoter activity. Nod1 deficiency results in impaired bacterial clearance and increased proinflammatory cytokine at 24hrs post-infection.
Nod1 is expressed by trophoblast cells across gestation and may have a role in mediating infection-associated inflammation and prematurity. Activation of Nod1 by bacterial peptidoglycan-derived peptide induces maternal-fetal inflammation and preterm labour.
Nod1 KO mice were protected from high-fat diet induced inflammation, lipid accumulation, and peripheral insulin intolerance. Ex vivo, Nod1 activation by bacterial peptidoglycan mimetics induces proinflammatory cytokine secretion and impaired insulin-stimulated glucose uptake in adipocytes. Hence, Nod1 is a plausible, new link between innate immunity and metabolism.
Nod1 and Nod2 synergize with Tlr4 in dendritic cells to increase IL12 production and enhance invariant natural killer T (iNKT) cell activation, and are important regulators of the IFN gamma response by iNKT cells during S. typhimurium and L. monocytogenes infections.
Salmonella enterica serovar Typhimurium Î?msbB that possesses a modified lipid A triggers exacerbated colitis in the absence of Nod1 and/or Nod2, which is likely due to increased Tlr2 stimulation.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||||
| Summary |
[Homo sapiens] NOD1 and NOD2 represent central players in the control of the immune responses to bacterial infections and inflammation.
[Homo sapiens] NOD1 and NOD2 can induce CCL5 (RANTES) through NF-kappaB pathway, orchestrating the global Nod-dependent immune defence during bacterial infections.
[Homo sapiens] NOD1 and NOD2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry.
[Homo sapiens] NOD1 plays an important role in host defence against bacterial infection by regulating direct killing of Helicobacter pylori bacteria by antimicrobial peptides.
[Homo sapiens] NOD1-dependent responses account for host resistance against T. cruzi infection by mechanisms independent of cytokine production.
[Homo sapiens] NOD1 plays a role in priming innate defences, facilitating a rapid response to infection by recognizing peptidoglycan from microbiota and enhancing killing of pathogens by bone marrow-derived neutrophils.
[Homo sapiens] NOD1 is a peripheral peptidoglycan intracellular sensor and is important for the progression and pathogenesis of experimental autoimmune encephalomyelitis (animal model of multiple sclerosis).
[Homo sapiens] NOD1 detects heat-killed Legionella pneumophila and stimulates NFkB and IFN-beta promoter activity. NOD1 deficiency results in impaired bacterial clearance and increased proinflammatory cytokine at 24hrs post-infection. (Demonstrated in murine model)
[Homo sapiens] NOD1 is expressed by trophoblast cells across gestation and may have a role in mediating infection-associated inflammation and prematurity. Activation of NOD1 by bacterial peptidoglycan-derived peptide induces maternal-fetal inflammation and preterm labour.
[Homo sapiens] Nod1 KO mice were protected from high-fat diet induced inflammation, lipid accumulation, and peripheral insulin intolerance. Ex vivo, NOD1 activation by bacterial peptidoglycan mimetics induces proinflammatory cytokine secretion and impaired insulin-stimulated glucose uptake in adipocytes. Hence, NOD1 is a plausible, new link between innate immunity and metabolism. (Demonstrated in murine model)
[Homo sapiens] Helicobacter pylori infection of gastric epithelial cells activates NOD1 to enhance IFN-gamma signalling.
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| Entrez Gene | |||||||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106100:
This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Oct 2009] This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5\' UTR have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Oct 2009] |
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| Gene Information | |||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 6:54923942-54972612 | ||||||||||||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||
| Band | B3 | ||||||||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||||
| REACTOME |
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
MyD88 cascade initiated on plasma membrane pathway
Cytokine Signaling in Immune system pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
activated TAK1 mediates p38 MAPK activation pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll-Like Receptors Cascades pathway
Signaling by Interleukins pathway
NOD1/2 Signaling Pathway pathway
MyD88 dependent cascade initiated on endosome pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Activated TLR4 signalling pathway
Interleukin-1 signaling pathway
MyD88-independent cascade pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG |
NOD-like receptor signaling pathway pathway
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| INOH | |||||||||||||||||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||||
| REACTOME |
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
activated TAK1 mediates p38 MAPK activation pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
NOD1/2 Signaling Pathway pathway
Interleukin-1 signaling pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
MAP kinase activation in TLR cascade pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Immune System pathway
Signaling by Interleukins pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
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| KEGG |
Epithelial cell signaling in Helicobacter pylori infection pathway
NOD-like receptor signaling pathway pathway
Shigellosis pathway
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| INOH | |||||||||||||||||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||||||||||||||||
| SwissProt | Q8BHB0 | ||||||||||||||||||||||||||||||||||||
| TrEMBL | Q540J8 | ||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||
| Entrez Gene | 107607 | ||||||||||||||||||||||||||||||||||||
| UniGene | Mm.28498 | ||||||||||||||||||||||||||||||||||||
| RefSeq | NM_001171007 NM_172729 XM_006505277 | ||||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||||
| CCDS | CCDS20160 | ||||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||
| MGI ID | MGI:1341839 | ||||||||||||||||||||||||||||||||||||
| MGI Symbol | Nod1 | ||||||||||||||||||||||||||||||||||||
| EMBL | AK082663 AK089662 AK137585 AY160222 BC042670 BC043670 CH466597 | ||||||||||||||||||||||||||||||||||||
| GenPept | AAH42670 AAH43670 AAN52479 BAC38566 BAC40940 BAE23420 EDK98713 | ||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | 107607 | ||||||||||||||||||||||||||||||||||||