|Mus musculus Gene: Il33|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||interleukin 33|
|Synonyms||9230117N10Rik; Il-33; Il1f11; NF-HEV|
|Useful resources||Stemformatics EHFPI ImmGen|
Il33 is produced in alveolar macrophages that have been infected with Influenza A virus. The Il33-Il13 signalling axis is required for airway hyper-reactivity in asthma.
Innate lymphoid cells responding to Il33 mediate airway hyperreactivity independently of adaptive immunity.
IL33 predominantly elicits group 2 innate lymphoid cells (ILC2) responses, and IL25 simultaneously elicits phenotypically and functionally distinct ILC2 and multipotent progenitor type 2 cell populations at multiple tissue sites.
Chitin induces IL25, IL33, and TSLP which are required to stimulate ILC2 production of IL5 and IL13. IL5 and IL13, in turn, are required for the accumulation of eosinophils and alternatively activated macrophages that are associated with allergy.
Il33 prevents the development of experimental cerebral malaria by orchestrating a protective immune response via type-2 innate lymphoid cells, M2 macrophages and regulatory T cells.
Cigarette smoke decreases Il1rl1 expression on group 2 innate lymphoid cells while elevating Il1rl1 expression on macrophages and natural killer cells, thus altering Il33 responsiveness within the lung to infection.
Group 2 innate lymphoid cell (ILC2)-intrinsic Il33 signalling and Icosl expression promote regulatory T cell accumulation, whereas the inflammatory cytokine Ifng counter-regulates these effects, in part through direct effects on ILC2s.
Il33-dependent group 2 innate lymphoid cells (ILC2s) signal via Areg-Egfr in damaged epithelia to restore epithelial barrier function and maintain tissue homeostasis.
|Summary||Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.|
|Genomic Location||Chromosome 19:29925114-29960718|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
|No orthologs found for this gene|
Cytosolic DNA-sensing pathway pathway
|UniProt Splice Variant|
|RefSeq||NM_001164724 NM_133775 XM_006527463|
|RNA Seq Atlas|