Version 5.4
| Mus musculus Gene: Irf3 | |||||||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-181123.6 | ||||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||
| Gene Symbol | Irf3 | ||||||||||||||||||||||||||||||||||||||
| Gene Name | interferon regulatory factor 3 | ||||||||||||||||||||||||||||||||||||||
| Synonyms | C920001K05Rik; IRF-3 | ||||||||||||||||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000003184 | ||||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
interferon regulatory factor 3
interferon regulatory factor 3
interferon regulatory factor 3
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||||||||||||||||||
| Summary |
Irf3 is strongly phosphorylated at the late stages of a Sindbis virus infection to mount antiviral responses in human embryonic kidney cells. (Demonstrated in human)
Irf3 is involved in the innate immune recognition of Plasmodium falciparum AT-rich DNA and in the subsequent induction of type I IFNs. Mice lacking Irf3/Irf7 are resistant to otherwise lethal cerebral malaria.
Irf3 suppresses neuroinflammation through regulation of immunomodulatory mmu-mir-155 microRNA expression in astrocytes. (Demonstrated in human)
HIV accessory protein Vpu targets Irf3 to endolysosome for proteolytic degradation to avoid antiviral immune responses. (Demonstrated in human)
Endoplasmic reticulum stress primes macrophages to respond to innate immunity stimuli by activating IRF3.
Plasmodium RNA is a pathogen-associated molecular pattern (PAMP) capable of activating a type I IFN response via the cytosolic pattern recognition receptors Ifih1 and Mavs, as well as via transcription factors Irf3 and Irf7.
Il28ra (Ifnlr1), Stat1 and Irf3 are required for antibiotics to prevent persistent murine norovirus infection.
The innate immune system plays a role in immunogenic tumour recognition. Tumor-cell-derived DNA triggers Ifnb1 production and dendritic cell activation via Tmem173 and Irf3 cytosolic DNA sensing pathways.
Aberrant mitochondrial DNA (mtDNA) packaging promotes escape of mtDNA into the cytosol, where it engages the DNA sensor Mb21d1 and promotes Tmem173-Irf3-dependent signalling to elevate IFN-stimulated gene expression, potentiate type I IFN responses and confer broad viral resistance.
Ppp4c, a serine/threonine phosphatase, directly binds to Tbk1 upon virus infection to dephosphorylate Tbk1 and inhibit Tbk1 activation, and subsequently restrain Irf3 activation, resulting in suppressed production of type I IFN and IFN-stimulated genes.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||||||
| Summary |
[Homo sapiens] IRF3 is a transcription factor that activates type-1 interferon (IFN) and IFN responsive genes.
[Homo sapiens] IRF3 is directly activated after virus infection and functions as a key activator of the intermediate/early alpha/beta interferon (IFN) genes as well as the RANTES chemokine gene.
[Homo sapiens] IRF3 transcription factor induces type I interferons (IFNs) and elicits innate antiviral response. TMEM173 (MITA) is a critical mediator of virus-triggered IRF3 activation and IFN expression.
[Homo sapiens] IRF3 phosphorylation is virus-inducible and results in IRF3 alteration of protein conformation to permit nuclear translocation, association with transcriptional partners, and primary activation of interferon (IFN)- and IFN-responsive genes.
[Homo sapiens] IRF3 is strongly phosphorylated at the late stages of a Sindbis virus infection to mount antiviral responses in human embryonic kidney cells.
[Homo sapiens] IRF3 is involved in the innate immune recognition of Plasmodium falciparum AT-rich DNA and in the subsequent induction of type I IFNs. Mice lacking Irf3/Irf7 are resistant to otherwise lethal cerebral malaria. (Demonstrated in mouse)
[Homo sapiens] IRF3 suppresses neuroinflammation through regulation of immunomodulatory MIR155 microRNA expression in astrocytes.
[Homo sapiens] HIV accessory protein Vpu targets IRF3 to endolysosome for proteolytic degradation to avoid antiviral immune responses.
[Homo sapiens] During the transcriptional response to Sendai virus infection, POLR2F(RNA Pol II) is recruited by IRF3 and NFκB to control virus induced gene activation.
[Homo sapiens] Vpu, an accessory protein encoded by HIV-1, contributes to the attenuation of the anti-viral response by partial inactivation of IRF3 while host cells undergo apoptosis.
[Homo sapiens] Hepatitis B virus (HBV) polymerase inhibits TMEM173-stimulated IRF3 activation and IFNB1 induction.
[Homo sapiens] Stimulation of TMEM173-dependent IRF3 activation by ultraviolet radiation is due to apoptotic signalling-dependent disruption of ULK1, a pro-autophagic protein that negatively regulates TMEM173.
[Homo sapiens] PQBP1 directly binds to reverse-transcribed HIV-1 DNA and interacts with MB21D1 to initiate an IRF3-dependent innate response
[Homo sapiens] 4-(2-chloro-6-fluorobenzyl)-N-(furan-2-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (G10) requires STING to trigger IRF3/IFN-associated transcription in human fibroblasts and subsequently blocking replication of Chikungunya virus, Venezuelan Encephalitis virus, and Sindbis virus.
[Homo sapiens] Influenza B virus induces IRF3 activation and IL29 (IFNL1) gene expression without a requirement for viral protein synthesis or replication and DDX58 is the critical pattern recognition receptor needed for IRF3 activation.
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| Entrez Gene | |||||||||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126456:
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] |
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| Gene Information | |||||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 7:44997648-45002848 | ||||||||||||||||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||||||||||||||||
| Band | B3 | ||||||||||||||||||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 79 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||||||
| REACTOME |
Toll Like Receptor 3 (TLR3) Cascade pathway
Innate Immune System pathway
Hemostasis pathway
Cytokine Signaling in Immune system pathway
IRF3 mediated activation of type 1 IFN pathway
Antiviral mechanism by IFN-stimulated genes pathway
Negative regulators of RIG-I/MDA5 signaling pathway
ISG15 antiviral mechanism pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
Immune System pathway
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production pathway
TRAF6 mediated IRF7 activation pathway
Factors involved in megakaryocyte development and platelet production pathway
Interferon gamma signaling pathway
Interferon Signaling pathway
IRF3-mediated induction of type I IFN pathway
Toll-Like Receptors Cascades pathway
Cytosolic sensors of pathogen-associated DNA pathway
STING mediated induction of host immune responses pathway
Regulation of innate immune responses to cytosolic DNA pathway
Activated TLR4 signalling pathway
MyD88-independent cascade pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
TRIF-mediated TLR3/TLR4 signaling pathway
TRAF3-dependent IRF activation pathway pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG |
Toll-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
Hepatitis C pathway
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| INOH | |||||||||||||||||||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||||||
| REACTOME |
IRF3 mediated activation of type 1 IFN pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
STING mediated induction of host immune responses pathway
TRAF6 mediated IRF7 activation pathway
Negative regulators of RIG-I/MDA5 signaling pathway
TRAF3-dependent IRF activation pathway pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Interferon alpha/beta signaling pathway
ISG15 antiviral mechanism pathway
Interferon gamma signaling pathway
Factors involved in megakaryocyte development and platelet production pathway
IRF3-mediated induction of type I IFN pathway
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production pathway
Antiviral mechanism by IFN-stimulated genes pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Interferon Signaling pathway
Regulation of innate immune responses to cytosolic DNA pathway
Immune System pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Cytosolic sensors of pathogen-associated DNA pathway
Hemostasis pathway
STING mediated induction of host immune responses pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Factors involved in megakaryocyte development and platelet production pathway
ISG15 antiviral mechanism pathway
Activated TLR4 signalling pathway
MyD88-independent cascade pathway
Cytosolic sensors of pathogen-associated DNA pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Cytokine Signaling in Immune system pathway
Hemostasis pathway
Immune System pathway
Antiviral mechanism by IFN-stimulated genes pathway
IRF3-mediated induction of type I IFN pathway
IRF3 mediated activation of type 1 IFN pathway
Toll-Like Receptors Cascades pathway
Negative regulators of RIG-I/MDA5 signaling pathway
TRAF3-dependent IRF activation pathway pathway
Interferon Signaling pathway
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production pathway
TRAF6 mediated IRF7 activation pathway
Innate Immune System pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG |
Toll-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
Hepatitis C pathway
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| INOH | |||||||||||||||||||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||||||||||||||||||
| SwissProt | P70671 | ||||||||||||||||||||||||||||||||||||||
| TrEMBL | O54726 Q3U9K6 | ||||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||
| Entrez Gene | 54131 | ||||||||||||||||||||||||||||||||||||||
| UniGene | |||||||||||||||||||||||||||||||||||||||
| RefSeq | NM_016849 | ||||||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||||||
| CCDS | CCDS21224 | ||||||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||||
| MGI ID | MGI:1859179 | ||||||||||||||||||||||||||||||||||||||
| MGI Symbol | Irf3 | ||||||||||||||||||||||||||||||||||||||
| EMBL | AF036341 AK145977 AK151750 AK152689 BC050882 CH466603 U75839 U75840 | ||||||||||||||||||||||||||||||||||||||
| GenPept | AAB36924 AAB36925 AAC68814 AAH50882 BAE26800 BAE30660 BAE31420 EDL22782 EDL22786 | ||||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | 54131 | ||||||||||||||||||||||||||||||||||||||