Version 5.4
Mus musculus Gene: Msh6
Summary
InnateDB Gene IDBG-201548.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Msh6
Gene Name mutS homolog 6 (E. coli)
Synonyms AU044881; AW550279; GTBP; Gtmbp
Species Mus musculus
Ensembl Gene ENSMUSG00000005370
Encoded Proteins
IDBP-201550
mutS homolog 6 (E. coli)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116062:
This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer. [provided by RefSeq, Jul 2008]
This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:87975050-87990883
Strand Forward strand
Band E4
Transcripts
ENSMUST00000005503 ENSMUSP00000005503
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 51 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0000400 four-way junction DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 DNA-dependent ATPase activity
GO:0016887 ATPase activity
GO:0030983 mismatched DNA binding
GO:0032137 guanine/thymine mispair binding
GO:0032138 single base insertion or deletion binding
GO:0032142 single guanine insertion binding
GO:0032143 single thymine insertion binding
GO:0032357 oxidized purine DNA binding
GO:0032405 MutLalpha complex binding
GO:0035064 methylated histone binding
GO:0043531 ADP binding
Biological Process
GO:0000710 meiotic mismatch repair
GO:0006200 ATP catabolic process
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0007131 reciprocal meiotic recombination
GO:0008340 determination of adult lifespan
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009411 response to UV
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0016447 somatic recombination of immunoglobulin gene segments
GO:0043570 maintenance of DNA repeat elements
GO:0045190 isotype switching
GO:0045910 negative regulation of DNA recombination
GO:0051096 positive regulation of helicase activity
GO:0097193 intrinsic apoptotic signaling pathway
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0032301 MutSalpha complex
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000116062
View Gene Order
ENSBTAG00000001424
Not yet available
Pathways
NETPATH
REACTOME
REACT_233397
DNA Repair pathway
REACT_236124
Mismatch Repair pathway
REACT_240368
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
KEGG
mmu05210
Colorectal cancer pathway
mmu03430
Mismatch repair pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228145
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
REACT_228013
Mismatch Repair pathway
REACT_216
DNA Repair pathway
KEGG
hsa05210
Colorectal cancer pathway
hsa03430
Mismatch repair pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt P54276
TrEMBL Q9CRH0
UniProt Splice Variant
Entrez Gene 17688
UniGene Mm.18210
RefSeq NM_010830
OMIM
CCDS CCDS29021
HPRD
IMGT
MGI ID MGI:1343961
MGI Symbol Msh6
EMBL AF031085 AF031086 AF031087 AK010643 BC051160 BC051634 U42190 U61388 U61389
GenPept AAB39930 AAB39931 AAB88445 AAC53034 AAH51160 AAH51634 BAB27085
RNA Seq Atlas 17688

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca