Version 5.4
| Mus musculus Gene: E2f1 | |||||||||||||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-210416.6 | ||||||||||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||||||
| Gene Symbol | E2f1 | ||||||||||||||||||||||||||||||||||||||||||||
| Gene Name | E2F transcription factor 1 | ||||||||||||||||||||||||||||||||||||||||||||
| Synonyms | E2F-1; mKIAA4009 | ||||||||||||||||||||||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000027490 | ||||||||||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
E2F transcription factor 1
E2F transcription factor 1
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||||||||||||||||||||||||
| Summary |
E2f1 is important for normal inflammatory response to systemic LPS by enhancing the production of Il6 and Tnfa in murine macrophages.
E2f1 directly binds to the promoter of Tlr3 to inhibit transcription.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||||||||||||
| Summary |
[Homo sapiens] E2F1 is important for normal inflammatory response to systemic LPS by enhancing the production of IL6 and TNFA in macrophages. (Demonstrated in murine model)
[Homo sapiens] E2F1 directly binds to the promoter of TLR3 to inhibit transcription. (Demonstrated in mice)
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| Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101412:
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008] The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 2:154559407-154569892 | ||||||||||||||||||||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||||||||||
| Band | H1 | ||||||||||||||||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 149 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||||||||||||
| REACTOME |
Cell Cycle, Mitotic pathway
G1 Phase pathway
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
G2 Phase pathway
DNA Replication pathway
G0 and Early G1 pathway
Cell Cycle pathway
Cyclin D associated events in G1 pathway
CDC6 association with the ORC:origin complex pathway
Regulation of DNA replication pathway
M/G1 Transition pathway
Mitotic G2-G2/M phases pathway
Association of licensing factors with the pre-replicative complex pathway
G1/S Transition pathway
Mitotic G1-G1/S phases pathway
G1/S-Specific Transcription pathway
E2F mediated regulation of DNA replication pathway
DNA Replication Pre-Initiation pathway
Assembly of the pre-replicative complex pathway
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| KEGG |
Bladder cancer pathway
Melanoma pathway
Cell cycle pathway
Glioma pathway
Small cell lung cancer pathway
Prostate cancer pathway
Chronic myeloid leukemia pathway
Non-small cell lung cancer pathway
Pancreatic cancer pathway
Pathways in cancer pathway
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| INOH | |||||||||||||||||||||||||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||||||||||||
| REACTOME |
Association of licensing factors with the pre-replicative complex pathway
CDC6 association with the ORC:origin complex pathway
Assembly of the pre-replicative complex pathway
G0 and Early G1 pathway
G1/S-Specific Transcription pathway
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
E2F mediated regulation of DNA replication pathway
Cyclin D associated events in G1 pathway
G2 Phase pathway
Pre-NOTCH Transcription and Translation pathway
Activation of NOXA and translocation to mitochondria pathway
Activation of PUMA and translocation to mitochondria pathway
DNA Replication pathway
G1 Phase pathway
Cellular responses to stress pathway
Oncogene Induced Senescence pathway
Pre-NOTCH Expression and Processing pathway
Mitotic G1-G1/S phases pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Apoptosis pathway
Signal Transduction pathway
Cell Cycle pathway
Activation of BH3-only proteins pathway
Cellular Senescence pathway
Signaling by NOTCH pathway
M/G1 Transition pathway
Cell Cycle, Mitotic pathway
Intrinsic Pathway for Apoptosis pathway
Mitotic G2-G2/M phases pathway
Regulation of DNA replication pathway
Oxidative Stress Induced Senescence pathway
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| KEGG |
Non-small cell lung cancer pathway
Cell cycle pathway
Melanoma pathway
Bladder cancer pathway
Glioma pathway
Small cell lung cancer pathway
Prostate cancer pathway
Chronic myeloid leukemia pathway
Pancreatic cancer pathway
Pathways in cancer pathway
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| INOH | |||||||||||||||||||||||||||||||||||||||||||||
| PID NCI |
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Notch-mediated HES/HEY network
p75(NTR)-mediated signaling
E2F transcription factor network
IL2 signaling events mediated by PI3K
Regulation of Telomerase
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| Cross-References | |||||||||||||||||||||||||||||||||||||||||||||
| SwissProt | Q61501 | ||||||||||||||||||||||||||||||||||||||||||||
| TrEMBL | Q547J6 | ||||||||||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||||||
| Entrez Gene | 13555 | ||||||||||||||||||||||||||||||||||||||||||||
| UniGene | Mm.18036 Mm.441323 | ||||||||||||||||||||||||||||||||||||||||||||
| RefSeq | NM_007891 NM_001291105 XM_006498694 | ||||||||||||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||||||||||||
| CCDS | CCDS16935 CCDS71165 | ||||||||||||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||||||||||
| MGI ID | MGI:101941 | ||||||||||||||||||||||||||||||||||||||||||||
| MGI Symbol | E2f1 | ||||||||||||||||||||||||||||||||||||||||||||
| EMBL | AF483514 AF483515 AK153968 BC052160 CH466551 L21973 | ||||||||||||||||||||||||||||||||||||||||||||
| GenPept | AAA83217 AAH52160 AAL90788 AAL90789 BAE32285 EDL06086 | ||||||||||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | 13555 | ||||||||||||||||||||||||||||||||||||||||||||