InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TP53

Summary

InnateDB Gene

IDBG-26364.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TP53

Gene Name

tumor protein p53

Synonyms

BCC7; LFS1; P53; TRP53

Species

Homo sapiens

Ensembl Gene

ENSG00000141510

Encoded Proteins

IDBP-26366

tumor protein p53

IDBP-26368

tumor protein p53

IDBP-366324

tumor protein p53

IDBP-366361

tumor protein p53

IDBP-366363

tumor protein p53

IDBP-366364

tumor protein p53

IDBP-809990

tumor protein p53

IDBP-809992

tumor protein p53

IDBP-809996

tumor protein p53

IDBP-480434

tumor protein p53

IDBP-477072

tumor protein p53

IDBP-481132

tumor protein p53

IDBP-480240

tumor protein p53

IDBP-759854

IDBP-809997

tumor protein p53

IDBP-809999

tumor protein p53

IDBP-810000

tumor protein p53

IDBP-810002

tumor protein p53

IDBP-810009

tumor protein p53

IDBP-810010

tumor protein p53

IDBP-810012

tumor protein p53

IDBP-810016

tumor protein p53

IDBP-810019

tumor protein p53

IDBP-810020

tumor protein p53

IDBP-810049

tumor protein p53

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21483755

TP53 binds to canonical and non-canonical promoter regions of the human TLR gene family and up-regulates the expression of TLRs. The activation of TP53 can directly influence the TLR-mediated induction of cytokines.

PMID 22105999

TP53 serves as a host antiviral factor and enhances both the innate and adaptive immune responses to influenza A virus. (Demonstrated in mice)

PMID 25505178

Coronavirus engages papain-like proteases to escape from the innate antiviral response of the host by inhibiting TP53-IRF7-IFNB1 signalling.

InnateDB Annotation from Orthologs

Summary

PMID 22105999

[Mus musculus] Tpr53 serves as a host antiviral factor and enhances both the innate and adaptive immune responses to influenza A virus.

Entrez Gene

Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:7661779-7687550

Strand

Reverse strand

Band

p13.1

Transcripts

ENST00000269305	ENSP00000269305
ENST00000359597	ENSP00000352610
ENST00000413465	ENSP00000410739
ENST00000420246	ENSP00000391127
ENST00000455263	ENSP00000398846
ENST00000445888	ENSP00000391478
ENST00000504290	ENSP00000484409
ENST00000510385	ENSP00000478499
ENST00000504937	ENSP00000481179
ENST00000509690	ENSP00000425104
ENST00000514944	ENSP00000423862
ENST00000505014
ENST00000508793	ENSP00000424104
ENST00000503591	ENSP00000426252
ENST00000576024	ENSP00000458393
ENST00000574684
ENST00000619186	ENSP00000484375
ENST00000618944	ENSP00000481401
ENST00000610623	ENSP00000477531
ENST00000610292	ENSP00000478219
ENST00000620739	ENSP00000481638
ENST00000622645	ENSP00000482222
ENST00000610538	ENSP00000480868
ENST00000619485	ENSP00000482537
ENST00000604348	ENSP00000473895
ENST00000617185	ENSP00000482258
ENST00000615910	ENSP00000482903

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1328 experimentally validated interaction(s) in this database.
They are also associated with 85 interaction(s) predicted by orthology.

Experimentally validated
Total	1328 [view]
Protein-Protein	1244 [view]
Protein-DNA	66 [view]
Protein-RNA	0
DNA-DNA	18 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	85 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001085	RNA polymerase II transcription factor binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0002020	protease binding
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003684	damaged DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0030971	receptor tyrosine kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0035033	histone deacetylase regulator activity
GO:0035035	histone acetyltransferase binding
GO:0042802	identical protein binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0047485	protein N-terminus binding
GO:0051087	chaperone binding
GO:0051721	protein phosphatase 2A binding
GO:0097371	MDM2/MDM4 family protein binding

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000733	DNA strand renaturation
GO:0001701	in utero embryonic development
GO:0001756	somitogenesis
GO:0001836	release of cytochrome c from mitochondria
GO:0002309	T cell proliferation involved in immune response
GO:0002326	B cell lineage commitment
GO:0002360	T cell lineage commitment
GO:0002931	response to ischemia
GO:0006284	base-excision repair
GO:0006289	nucleotide-excision repair
GO:0006302	double-strand break repair
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006461	protein complex assembly
GO:0006915	apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0006979	response to oxidative stress
GO:0006983	ER overload response
GO:0007049	cell cycle
GO:0007050	cell cycle arrest
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0007265	Ras protein signal transduction
GO:0007275	multicellular organismal development
GO:0007369	gastrulation
GO:0007406	negative regulation of neuroblast proliferation
GO:0007417	central nervous system development
GO:0007569	cell aging
GO:0007596	blood coagulation
GO:0008104	protein localization
GO:0008156	negative regulation of DNA replication
GO:0008283	cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008340	determination of adult lifespan
GO:0009303	rRNA transcription
GO:0009411	response to UV
GO:0009651	response to salt stress
GO:0009792	embryo development ending in birth or egg hatching
GO:0010165	response to X-ray
GO:0010332	response to gamma radiation
GO:0010666	positive regulation of cardiac muscle cell apoptotic process
GO:0016032	viral process
GO:0021549	cerebellum development
GO:0030154	cell differentiation
GO:0030308	negative regulation of cell growth
GO:0030330	DNA damage response, signal transduction by p53 class mediator
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031065	positive regulation of histone deacetylation
GO:0031497	chromatin assembly
GO:0031571	mitotic G1 DNA damage checkpoint
GO:0032461	positive regulation of protein oligomerization
GO:0033077	T cell differentiation in thymus
GO:0034103	regulation of tissue remodeling
GO:0034613	cellular protein localization
GO:0034644	cellular response to UV
GO:0035264	multicellular organism growth
GO:0035690	cellular response to drug
GO:0035794	positive regulation of mitochondrial membrane permeability
GO:0042127	regulation of cell proliferation
GO:0042149	cellular response to glucose starvation
GO:0042493	response to drug
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043523	regulation of neuron apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046677	response to antibiotic
GO:0046902	regulation of mitochondrial membrane permeability
GO:0048147	negative regulation of fibroblast proliferation
GO:0048568	embryonic organ development
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051097	negative regulation of helicase activity
GO:0051262	protein tetramerization
GO:0051276	chromosome organization
GO:0051402	neuron apoptotic process
GO:0051726	regulation of cell cycle
GO:0070243	regulation of thymocyte apoptotic process
GO:0070245	positive regulation of thymocyte apoptotic process
GO:0070266	necroptotic process
GO:0071158	positive regulation of cell cycle arrest
GO:0071456	cellular response to hypoxia
GO:0071479	cellular response to ionizing radiation
GO:0071850	mitotic cell cycle arrest
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0090343	positive regulation of cell aging
GO:0090399	replicative senescence
GO:0090403	oxidative stress-induced premature senescence
GO:0097193	intrinsic apoptotic signaling pathway
GO:0097252	oligodendrocyte apoptotic process
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901525	negative regulation of macromitophagy
GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process
GO:2000378	negative regulation of reactive oxygen species metabolic process
GO:2000379	positive regulation of reactive oxygen species metabolic process
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0000785	chromatin
GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005657	replication fork
GO:0005669	transcription factor TFIID complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0016363	nuclear matrix
GO:0016604	nuclear body
GO:0016605	PML body
GO:0043234	protein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000059552

View Gene Order

ENSBTAG00000001069

Not yet available

Pathways

NETPATH

NetPath_4

EGFR1 pathway

NetPath_7

TGF_beta_Receptor pathway

NetPath_9

TNFalpha pathway

NetPath_114

Oncostatin_M pathway

REACTOME

REACT_346

Transcriptional activation of cell cycle inhibitor p21 pathway

REACT_20549

Autodegradation of the E3 ubiquitin ligase COP1 pathway

REACT_309

Stabilization of p53 pathway

REACT_1625

p53-Dependent G1 DNA Damage Response pathway

REACT_24970

Factors involved in megakaryocyte development and platelet production pathway

REACT_118568

Pre-NOTCH Transcription and Translation pathway

REACT_1194

Activation of NOXA and translocation to mitochondria pathway

REACT_121

Activation of PUMA and translocation to mitochondria pathway

REACT_85

p53-Dependent G1/S DNA damage checkpoint pathway

REACT_120956

Cellular responses to stress pathway

REACT_169325

Oncogene Induced Senescence pathway

REACT_118744

Pre-NOTCH Expression and Processing pathway

REACT_169121

Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway

REACT_578

Apoptosis pathway

REACT_111102

Signal Transduction pathway

REACT_115566

Cell Cycle pathway

REACT_169185

DNA Damage/Telomere Stress Induced Senescence pathway

REACT_202

Transcriptional activation of p53 responsive genes pathway

REACT_697

Activation of BH3-only proteins pathway

REACT_169274

Cellular Senescence pathway

REACT_299

Signaling by NOTCH pathway

REACT_964

Intrinsic Pathway for Apoptosis pathway

REACT_2254

G1/S DNA Damage Checkpoints pathway

REACT_169436

Oxidative Stress Induced Senescence pathway

REACT_604

Hemostasis pathway

REACT_1538

Cell Cycle Checkpoints pathway

KEGG

hsa05210

Colorectal cancer pathway

hsa05223

Non-small cell lung cancer pathway

hsa04310

Wnt signaling pathway pathway

hsa04110

Cell cycle pathway

hsa04210

Apoptosis pathway

hsa04010

MAPK signaling pathway pathway

hsa05218

Melanoma pathway

hsa05216

Thyroid cancer pathway

hsa05213

Endometrial cancer pathway

hsa05219

Bladder cancer pathway

hsa05214

Glioma pathway

hsa05222

Small cell lung cancer pathway

hsa05215

Prostate cancer pathway

hsa05217

Basal cell carcinoma pathway

hsa05220

Chronic myeloid leukemia pathway

hsa05212

Pancreatic cancer pathway

hsa04115

p53 signaling pathway pathway

hsa05014

Amyotrophic lateral sclerosis (ALS) pathway

hsa04722

Neurotrophin signaling pathway pathway

hsa05016

Huntington's disease pathway

hsa05200

Pathways in cancer pathway

hsa05160

Hepatitis C pathway

INOH

PID NCI

plk3_pathway

PLK3 signaling events

aurora_a_pathway

Aurora A signaling

p53downstreampathway

Direct p53 effectors

myc_activpathway

Validated targets of C-MYC transcriptional activation

lkb1_pathway

LKB1 signaling events

p53regulationpathway

p53 pathway

ap1_pathway

AP-1 transcription factor network

reg_gr_pathway

Glucocorticoid receptor regulatory network

p75ntrpathway

p75(NTR)-mediated signaling

hdac_classiii_pathway

Signaling events mediated by HDAC Class III

p38alphabetadownstreampathway

Signaling mediated by p38-alpha and p38-beta

hif1apathway

Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

bard1pathway

BARD1 signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_000546 NM_001126112 NM_001126113 NM_001126114 NM_001126115 NM_001126116 NM_001126117 NM_001126118 NM_001276695 NM_001276696 NM_001276697 NM_001276698 NM_001276699 NM_001276760 NM_001276761

HUGO

OMIM

CCDS

CCDS11118 CCDS45605 CCDS45606 CCDS73963 CCDS73964 CCDS73965 CCDS73966 CCDS73967 CCDS73968 CCDS73969 CCDS73970 CCDS73971

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas