InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CD86

Summary

InnateDB Gene

IDBG-52336.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD86

Gene Name

CD86 molecule

Synonyms

B7-2; B7.2; B70; CD28LG2; LAB72

Species

Homo sapiens

Ensembl Gene

ENSG00000114013

Encoded Proteins

IDBP-52338

CD86 molecule

IDBP-52340

CD86 molecule

IDBP-243241

CD86 molecule

IDBP-485278

CD86 molecule

IDBP-480834

CD86 molecule

IDBP-477338

CD86 molecule

IDBP-478977

CD86 molecule

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25549946

[Mus musculus] Tmem126a upregulates genes involved in antigen presentation; such as Icam1, MHC II, Cd86 and Cd40, via the Tlr4 signal transduction pathway.

Entrez Gene

Summary

This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:122055366-122121139

Strand

Forward strand

Band

q13.33

Transcripts

ENST00000330540	ENSP00000332049
ENST00000264468	ENSP00000264468
ENST00000393627	ENSP00000377248
ENST00000469710	ENSP00000418988
ENST00000493101	ENSP00000420230
ENST00000478390
ENST00000483949
ENST00000482356	ENSP00000419116
ENST00000478741	ENSP00000417195

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0015026	coreceptor activity

Biological Process

GO:0001878	response to yeast
GO:0002224	toll-like receptor signaling pathway
GO:0002309	T cell proliferation involved in immune response
GO:0002668	negative regulation of T cell anergy
GO:0006955	immune response
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007568	aging
GO:0008284	positive regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0016032	viral process
GO:0031295	T cell costimulation
GO:0032496	response to lipopolysaccharide
GO:0034341	response to interferon-gamma
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042102	positive regulation of T cell proliferation
GO:0042104	positive regulation of activated T cell proliferation
GO:0042110	T cell activation
GO:0042113	B cell activation
GO:0042493	response to drug
GO:0043011	myeloid dendritic cell differentiation
GO:0043017	positive regulation of lymphotoxin A biosynthetic process
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response
GO:0045404	positive regulation of interleukin-4 biosynthetic process
GO:0045630	positive regulation of T-helper 2 cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0051607	defense response to virus
GO:0071222	cellular response to lipopolysaccharide
GO:0071248	cellular response to metal ion
GO:0071345	cellular response to cytokine stimulus

Cellular Component

GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome