InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NPM1

Summary

InnateDB Gene

IDBG-57453.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPM1

Gene Name

nucleophosmin (nucleolar phosphoprotein B23, numatrin)

Synonyms

B23; NPM

Species

Homo sapiens

Ensembl Gene

ENSG00000181163

Encoded Proteins

IDBP-57455

nucleophosmin (nucleolar phosphoprotein B23, numatrin)

IDBP-57457

nucleophosmin (nucleolar phosphoprotein B23, numatrin)

IDBP-242817

nucleophosmin (nucleolar phosphoprotein B23, numatrin)

IDBP-478280

nucleophosmin (nucleolar phosphoprotein B23, numatrin)

IDBP-481901

nucleophosmin (nucleolar phosphoprotein B23, numatrin)

IDBP-478497

nucleophosmin (nucleolar phosphoprotein B23, numatrin)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:171387116-171411137

Strand

Forward strand

Band

q35.1

Transcripts

ENST00000296930	ENSP00000296930
ENST00000351986	ENSP00000341168
ENST00000393820	ENSP00000377408
ENST00000517671	ENSP00000428755
ENST00000521672	ENSP00000429485
ENST00000523339
ENST00000523622	ENSP00000428647
ENST00000518587
ENST00000521260
ENST00000521710
ENST00000519955
ENST00000524204

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 440 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	441 [view]
Protein-Protein	438 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003713	transcription coactivator activity
GO:0003723	RNA binding
GO:0004860	protein kinase inhibitor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0030957	Tat protein binding
GO:0042393	histone binding
GO:0042803	protein homodimerization activity
GO:0043023	ribosomal large subunit binding
GO:0043024	ribosomal small subunit binding
GO:0044822	poly(A) RNA binding
GO:0046982	protein heterodimerization activity
GO:0051059	NF-kappaB binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006281	DNA repair
GO:0006334	nucleosome assembly
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0006950	response to stress
GO:0007098	centrosome cycle
GO:0007165	signal transduction
GO:0007569	cell aging
GO:0008104	protein localization
GO:0008285	negative regulation of cell proliferation
GO:0010826	negative regulation of centrosome duplication
GO:0016032	viral process
GO:0032071	regulation of endodeoxyribonuclease activity
GO:0034080	centromere-specific nucleosome assembly
GO:0042255	ribosome assembly
GO:0043066	negative regulation of apoptotic process
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045727	positive regulation of translation
GO:0046599	regulation of centriole replication
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051259	protein oligomerization
GO:0060699	regulation of endoribonuclease activity
GO:0060735	regulation of eIF2 alpha phosphorylation by dsRNA

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0031616	spindle pole centrosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000057113

View Gene Order

ENSBTAG00000015316

Not yet available

Pathways

NETPATH

REACTOME

REACT_22186

Deposition of new CENPA-containing nucleosomes at the centromere pathway

REACT_9395

Nuclear import of Rev protein pathway

REACT_22172

Chromosome Maintenance pathway

REACT_22344

Nucleosome assembly pathway

REACT_115566

Cell Cycle pathway

REACT_6185

HIV Infection pathway

REACT_6288

Host Interactions of HIV factors pathway

REACT_6916

Interactions of Rev with host cellular proteins pathway

REACT_116125

Disease pathway

KEGG

INOH

PID NCI

myc_activpathway

Validated targets of C-MYC transcriptional activation

hif1_tfpathway

HIF-1-alpha transcription factor network

aurora_b_pathway

Aurora B signaling

Cross-References

SwissProt

P06748

TrEMBL

E5RI98 Q9NX34

UniProt Splice Variant

Entrez Gene

4869

UniGene

Hs.573436 Hs.600877 Hs.634598 Hs.647621 Hs.667403 Hs.735618

RefSeq

NM_001037738 NM_002520 NM_199185 XM_006714869

HUGO

HGNC:7910

OMIM

164040

CCDS

CCDS43399 CCDS4376 CCDS4377

HPRD

01246

IMGT

EMBL

AB042278 AB451236 AB451361 AC091980 AC093246 AK000472 AK290652 AY347529 AY740634 AY740635 AY740636 AY740637 AY740638 AY740639 AY740640 BC002398 BC008495 BC009623 BC012566 BC014349 BC016716 BC016768 BC016824 BC021668 BC021983 BC050628 BC107754 BT007011 CH471062 D45915 DQ303464 J02590 M23613 M26697 M28699 M31004 U04946 U41742 U41743 U89309 U89310 U89311 U89313 U89314 U89317 U89319 U89321 X16934

GenPept

AAA36380 AAA36385 AAA36473 AAA36474 AAA58386 AAA58698 AAB00112 AAB00113 AAB94739 AAH02398 AAH08495 AAH09623 AAH12566 AAH14349 AAH16716 AAH16768 AAH16824 AAH21668 AAH21983 AAH50628 AAI07755 AAP35657 AAQ24860 AAW67752 AAW67753 AAW67754 AAW67755 AAW67756 AAW67757 AAW67758 ABC40399 BAA08343 BAA91188 BAB40600 BAF83341 BAG70050 BAG70175 CAA34809 EAW61443 EAW61446

RNA Seq Atlas

4869