Bos taurus Gene: IRAKM | |||||||||||||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-634310.3 | ||||||||||||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||||||
Gene Symbol | IRAKM | ||||||||||||||||||||||||||||||||||||||||||||
Gene Name | interleukin-1 receptor-associated kinase 3 | ||||||||||||||||||||||||||||||||||||||||||||
Synonyms | IrakM | ||||||||||||||||||||||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000007636 | ||||||||||||||||||||||||||||||||||||||||||||
Encoded Proteins |
Interleukin-1 receptor-associated kinase M transcript variant 1Interleukin-1 receptor-associated kinase M transcript variant 2
Interleukin-1 receptor-associated kinase M transcript variant 1Interleukin-1 receptor-associated kinase M transcript variant 2
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Protein Structure | |||||||||||||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||||||||||||
Summary |
[Homo sapiens] IRAK3 upregulation by lipopolysaccharide (LPS) is largely dependent on TNF-alpha and LPS tolerance in human endotoxemia models is associated with IRAK3 up-regulation.
[Homo sapiens] IRAK3 selectively attenuates Pam3CSK4-induced MAPK14 (p38) activation through an IRAK1 independent and MKP1 dependent pathway.
[Homo sapiens] IRAK3 is part of the interleukin-1 receptor-associated kinase (IRAK) family of proteins that mediate activation of nuclear factor-kappaB (NF-kappaB) and mitogen-activated protein kinase (MAPK) pathways.
[Homo sapiens] IRAK3 is one of the negative regulators that contribute to the attenuation of NF-kappaB activation and it negatively regulates the alternative NF-kappaB pathway in a ligand-specific manner.
[Homo sapiens] IRAK3 induction and inhibition of kinase activity of IRAK1 are crucial to peptidoglycan-induced tolerance in macrophages.
[Homo sapiens] IRAK3 regulates Toll-like receptor (TLR) signalling and innate immune homeostasis where IRAK3 is induced upon TLR stimulation and negatively regulates TLR signalling.
[Homo sapiens] IRAK3 is critical to preventing deleterious neutrophil-dependent lung injury during influenza infection of the respiratory tract.
[Homo sapiens] IRAK3 is strongly expressed in resting alveolar macrophages and blunts TNF expression to protect the host from the injurious effect of bacterial-induced inflammation. The inhibitory function of IRAK3 is abolished when it is cleaved by CASP6, which allows the induction of the NFKB pathway and the expression of TNF.
[Homo sapiens] IRAK3 dampens the innate immune response in airway epithelial cells by inhibiting TLR2 signalling in an IL13-dependent manner.
[Homo sapiens] IRAK3 impairs host defence during pneumococcal pneumonia at the primary site of infection. (Demonstrated in mice)
[Mus musculus] Irak3 dampens the innate immune response in airway epithelial cells by inhibiting Tlr2 signalling in an Il13-dependent manner. (Demonstrated in human)
[Mus musculus] Irak3 impairs host defence during pneumococcal pneumonia at the primary site of infection.
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Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000090376:
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010] |
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Gene Information | |||||||||||||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 5:47796256-47839675 | ||||||||||||||||||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||||||||||
Band | |||||||||||||||||||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||||||||
NETPATH |
IL1 pathway
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REACTOME |
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Interleukin-1 signaling pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Immune System pathway
Signaling by Interleukins pathway
Activated TLR4 signalling pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Cytokine Signaling in Immune system pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Immune System pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Toll-Like Receptors Cascades pathway
Signaling by Interleukins pathway
Activated TLR4 signalling pathway
Interleukin-1 signaling pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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KEGG |
Apoptosis pathway
Neurotrophin signaling pathway pathway
Apoptosis pathway
Neurotrophin signaling pathway pathway
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INOH | |||||||||||||||||||||||||||||||||||||||||||||
PID NCI |
IL1-mediated signaling events
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Cross-References | |||||||||||||||||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||||||||||||||||
TrEMBL | B3FXL5 | ||||||||||||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||||||
Entrez Gene | 510342 | ||||||||||||||||||||||||||||||||||||||||||||
UniGene | Bt.31286 | ||||||||||||||||||||||||||||||||||||||||||||
RefSeq | NM_001190299 | ||||||||||||||||||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||||||||||||
EMBL | DAAA02013312 DAAA02013313 DAAA02013314 EU528624 | ||||||||||||||||||||||||||||||||||||||||||||
GenPept | ACD50137 | ||||||||||||||||||||||||||||||||||||||||||||
RNA Seq Atlas | 510342 | ||||||||||||||||||||||||||||||||||||||||||||