Bos taurus Gene: GPR77 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-639987.3 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | GPR77 | ||||||||||||||||||
Gene Name | C5a anaphylatoxin chemotactic receptor C5L2 | ||||||||||||||||||
Synonyms | C5L2 | ||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||
Ensembl Gene | ENSBTAG00000037735 | ||||||||||||||||||
Encoded Proteins |
C5a anaphylatoxin chemotactic receptor C5L2
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||
Summary |
[Homo sapiens] GPR77 is an alternate receptor for C5a and is negatively regulated by the TLR-signalling pathway. TLR-mediated inhibition of GPR77 results in the amplification of complement pro-inflammatory responses. (Demonstrated in murine model)
[Mus musculus] Gpr77 is an alternate receptor for C5a and is negatively regulated by the TLR-signalling pathway. TLR-mediated inhibition of Gpr77 results in the amplification of complement pro-inflammatory responses.
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Entrez Gene | |||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134830:
This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 18:54777175-54781917 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | |||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR ligand binding pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
GPCR ligand binding pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
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KEGG | |||||||||||||||||||
INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | Q08DZ7 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 522144 | ||||||||||||||||||
UniGene | Bt.45845 | ||||||||||||||||||
RefSeq | NM_001077947 XM_005219293 XM_005219294 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | |||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | BC123493 DAAA02047415 EF030605 | ||||||||||||||||||
GenPept | AAI23494 ABI98946 | ||||||||||||||||||
RNA Seq Atlas | 522144 | ||||||||||||||||||
Transcript Frequencies | |||||||||||||||||||
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).
Based on Data from Bovine Gene Atlas |
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