InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GPR77

Summary

InnateDB Gene

IDBG-639987.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPR77

Gene Name

C5a anaphylatoxin chemotactic receptor C5L2

Synonyms

C5L2

Species

Bos taurus

Ensembl Gene

ENSBTAG00000037735

Encoded Proteins

IDBP-692185

C5a anaphylatoxin chemotactic receptor C5L2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21630250

[Homo sapiens] GPR77 is an alternate receptor for C5a and is negatively regulated by the TLR-signalling pathway. TLR-mediated inhibition of GPR77 results in the amplification of complement pro-inflammatory responses. (Demonstrated in murine model)

PMID 21630250

[Mus musculus] Gpr77 is an alternate receptor for C5a and is negatively regulated by the TLR-signalling pathway. TLR-mediated inhibition of Gpr77 results in the amplification of complement pro-inflammatory responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134830:
This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:54777175-54781917

Strand

Forward strand

Band

Transcripts

ENSBTAT00000054501

ENSBTAP00000047680

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004944	C5a anaphylatoxin receptor activity
GO:0005515	protein binding

Biological Process

GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0032720	negative regulation of tumor necrosis factor production
GO:0050679	positive regulation of epithelial cell proliferation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090024	negative regulation of neutrophil chemotaxis
GO:1900165	negative regulation of interleukin-6 secretion
GO:2000482	regulation of interleukin-8 secretion