Version 5.4
Bos taurus Gene: BT.64603
Summary
InnateDB Gene IDBG-641456.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.64603
Gene Name casein kinase II subunit alpha
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012341
Encoded Proteins
IDBP-693821
casein kinase II subunit alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:61082324-61106498
Strand Forward strand
Band
Transcripts
ENSBTAT00000057062 ENSBTAP00000050939
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 325 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 325 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000101266
View Gene Order
ENSMUSG00000074698
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
NetPath_22
Leptin pathway
REACTOME
REACT_150260
Condensation of Prometaphase Chromosomes pathway
REACT_682
Mitotic Prometaphase pathway
REACT_22272
Signal transduction by L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_200668
WNT mediated activation of DVL pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_189085
Disease pathway
REACT_214014
Signaling by Wnt pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_188804
Cell Cycle pathway
REACT_241408
M Phase pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_256756
Mitotic Prometaphase pathway
REACT_261444
Axon guidance pathway
REACT_215461
Signal transduction by L1 pathway
REACT_196632
Condensation of Prometaphase Chromosomes pathway
REACT_219680
L1CAM interactions pathway
REACT_188576
Developmental Biology pathway
REACT_188257
Signal Transduction pathway
REACT_225118
WNT mediated activation of DVL pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
hsa04310
Wnt signaling pathway pathway
hsa04520
Adherens junction pathway
hsa04530
Tight junction pathway
mmu04530
Tight junction pathway
mmu04310
Wnt signaling pathway pathway
mmu04520
Adherens junction pathway
INOH
PID NCI
alphasynuclein_pathway
Alpha-synuclein signaling
ps1pathway
Presenilin action in Notch and Wnt signaling
bcr_5pathway
BCR signaling pathway
nfat_3pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
lis1pathway
Lissencephaly gene (LIS1) in neuronal migration and development
pdgfrapathway
PDGFR-alpha signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca