Bos taurus Gene: BT.64612 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-646834.3 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | BT.64612 | ||||||||||||||||||||||
Gene Name | protein numb homolog | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000011683 | ||||||||||||||||||||||
Encoded Proteins |
protein numb homolog
protein numb homolog
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||
Summary |
[Mus musculus] Nod2 driven inflammation is regulated by nitric oxide responsive Mir146 that facilitates activation of sonic hedgehog (SHH) signalling by targeting Numb expression.
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Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133961:
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 10:85126907-85183835 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | |||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH |
Notch pathway
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REACTOME |
Activated NOTCH1 Transmits Signal to the Nucleus pathway
Recycling pathway of L1 pathway
L1CAM interactions pathway
Developmental Biology pathway
Signaling by Hedgehog pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Signaling by NOTCH1 in Cancer pathway
Axon guidance pathway
Degradation of GLI1 by the proteasome pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signal Transduction pathway
Hedgehog 'off' state pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Disease pathway
Disease pathway
Recycling pathway of L1 pathway
Hedgehog 'off' state pathway
Signaling by NOTCH1 pathway
Activated NOTCH1 Transmits Signal to the Nucleus pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Degradation of GLI1 by the proteasome pathway
Signaling by NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Axon guidance pathway
L1CAM interactions pathway
Developmental Biology pathway
Signaling by Hedgehog pathway
Signal Transduction pathway
Signaling by NOTCH pathway
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KEGG |
Notch signaling pathway pathway
Notch signaling pathway pathway
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INOH | |||||||||||||||||||||||
PID NCI |
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Notch signaling pathway
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | F1MCY4 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 512187 | ||||||||||||||||||||||
UniGene | Bt.64612 | ||||||||||||||||||||||
RefSeq | NM_001101951 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | |||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | DAAA02029594 DAAA02029595 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 512187 | ||||||||||||||||||||||