InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: C5

Summary

InnateDB Gene

IDBG-83167.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gene Name

complement component 5

Synonyms

C5a; C5b; C5D; CPAMD4; ECLZB

Species

Homo sapiens

Ensembl Gene

ENSG00000106804

Encoded Proteins

IDBP-83169

complement component 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18039528

C5 is the fifth component of complement and is comprised of alpha (C5a) and beta (C5b) polypeptide chains, C5a is a complement anaphylatoxin that can stimulate the generation of nitric oxide along with the secretion of histamine and leukotriene LTC4 from several cell types and can bring about an increase in vascular permeability that facilitates eosinophil accumulation at sites of allergic inflammation.

PMID 10441679

C5 is the fifth component of complement and is comprised of alpha (C5a) and beta (C5b) polypeptide chains. C5b first associates with complement component 6 (C6), which in turn initiates the assembly of the cytolytic membrane attack complex (MAC).

PMID 21063021

C5 fragments are released from neutrophils upon their activation of the alternative complement pathway and this further amplifies neutrophil pro-inflammatory responses.

PMID 25539819

C5 (C5a) is a critical mediator in blood during Candida albicans infection.

PMID 26176669

Staphylococcus aureus-induced neutrophil dysfunction correlates with the loss of C5AR1 from the neutrophil cell surface and results in C5a (C5)-induced CEACAM8 overexpression.

InnateDB Annotation from Orthologs

Summary

PMID 25725105

[Mus musculus] Cfp plays a role in intestinal homeostasis in response to an infectious challenge to activate Hc (C5a), which in turn provides protection through Il6 expression by the epithelium.

Entrez Gene

Summary

The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:120952335-121050276

Strand

Reverse strand

Band

q33.2

Transcripts

ENST00000223642	ENSP00000223642
ENST00000480188
ENST00000489802
ENST00000466280
ENST00000460578

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004866	endopeptidase inhibitor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008009	chemokine activity
GO:0031714	C5a anaphylatoxin chemotactic receptor binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001701	in utero embryonic development
GO:0002523	leukocyte migration involved in inflammatory response
GO:0006874	cellular calcium ion homeostasis
GO:0006935	chemotaxis
GO:0006950	response to stress
GO:0006954	inflammatory response
GO:0006956	complement activation
GO:0006957	complement activation, alternative pathway
GO:0006958	complement activation, classical pathway
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0010700	negative regulation of norepinephrine secretion
GO:0010760	negative regulation of macrophage chemotaxis
GO:0010951	negative regulation of endopeptidase activity
GO:0019835	cytolysis
GO:0030449	regulation of complement activation
GO:0033602	negative regulation of dopamine secretion
GO:0042593	glucose homeostasis
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0050921	positive regulation of chemotaxis
GO:0060326	cell chemotaxis
GO:0090197	positive regulation of chemokine secretion