Version 5.4
Interaction: MCL1 :: HUWE1 XML
Summary
InnateDB Group ID 194223
Short name MCL1 :: HUWE1
Full name MCL1 interacts with HUWE1
Interaction type physical association
Participants
Participant 1
Molecule: IDBG-70116
Molecule type: protein
Species: Homo sapiens
HUGO: HUWE1
Full name: HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
Direction: input
Biological role: unspecified role
Participant 2
Molecule: IDBG-102145
Molecule type: protein
Species: Homo sapiens
HUGO: MCL1
Full name: myeloid cell leukemia sequence 1 (BCL2-related)
Direction: input
Biological role: unspecified role
Evidence Reference 1
InnateDB ID IDB-195151.2
Last Modified 2013-07-09
Review status Unreviewed by InnateDB [Report errors or provide feedback]
Source database BIOGRID
Source database ID BIOGRID-336467
PMID 16213503
Interaction detection method affinity chromatography technology
Host system invitro
Host organism
Cell status
Cell line
Cell type
Tissue type
Comment
Participants
Participant Identification Method Experimental Role Participant Accession
1) HUWE1 predetermined participant bait NP_113584
2) MCL1 predetermined participant prey 4170
Evidence Reference 2
InnateDB ID IDB-232168.2
Last Modified 2013-07-09
Review status Unreviewed by InnateDB [Report errors or provide feedback]
Source database BIOGRID
Source database ID BIOGRID-611486
PMID 21730980
Interaction detection method affinity chromatography technology
Host system invitro
Host organism
Cell status
Cell line
Cell type
Tissue type
Comment
Participants
Participant Identification Method Experimental Role Participant Accession
1) MCL1 predetermined participant bait 4170
2) HUWE1 predetermined participant prey NP_113584
Evidence Reference 3
InnateDB ID IDB-277712.2
Last Modified 2013-07-09
Review status Unreviewed by InnateDB [Report errors or provide feedback]
Source database BIOGRID
Source database ID BIOGRID-571908
PMID 20023629
Interaction detection method affinity chromatography technology
Host system invitro
Host organism
Cell status
Cell line
Cell type
Tissue type
Comment
Participants
Participant Identification Method Experimental Role Participant Accession
1) MCL1 predetermined participant bait 4170
2) HUWE1 predetermined participant prey NP_113584
Evidence Reference 4
InnateDB ID IDB-281631.2
Last Modified 2013-07-09
Review status Unreviewed by InnateDB [Report errors or provide feedback]
Source database BIOGRID
Source database ID BIOGRID-557301
PMID 21613222
Interaction detection method affinity chromatography technology
Host system invitro
Host organism
Cell status
Cell line
Cell type
Tissue type
Comment
Participants
Participant Identification Method Experimental Role Participant Accession
1) HUWE1 predetermined participant bait NP_113584
2) MCL1 predetermined participant prey 4170
Evidence Reference 5
InnateDB ID IDB-285326.2
Last Modified 2013-07-09
Review status Unreviewed by InnateDB [Report errors or provide feedback]
Source database BIOGRID
Source database ID BIOGRID-571911
PMID 20023629
Interaction detection method affinity chromatography technology
Host system invitro
Host organism
Cell status
Cell line
Cell type
Tissue type
Comment
Participants
Participant Identification Method Experimental Role Participant Accession
1) HUWE1 predetermined participant bait NP_113584
2) MCL1 predetermined participant prey 4170
Evidence Reference 6
InnateDB ID IDB-291889.2
Last Modified 2013-07-09
Review status Unreviewed by InnateDB [Report errors or provide feedback]
Source database BIOGRID
Source database ID BIOGRID-566410
PMID 21907705
Interaction detection method affinity chromatography technology
Host system invitro
Host organism
Cell status
Cell line
Cell type
Tissue type
Comment
Participants
Participant Identification Method Experimental Role Participant Accession
1) HUWE1 predetermined participant bait NP_113584
2) MCL1 predetermined participant prey 4170
Evidence Reference 7
InnateDB ID IDB-292918.2
Last Modified 2013-07-09
Review status Unreviewed by InnateDB [Report errors or provide feedback]
Source database BIOGRID
Source database ID BIOGRID-566403
PMID 21907705
Interaction detection method affinity chromatography technology
Host system invitro
Host organism
Cell status
Cell line
Cell type
Tissue type
Comment
Participants
Participant Identification Method Experimental Role Participant Accession
1) MCL1 predetermined participant bait 4170
2) HUWE1 predetermined participant prey NP_113584
Evidence Reference 8
InnateDB ID IDB-315461.1
Last Modified 2012-02-14
Review status Unreviewed by InnateDB [Report errors or provide feedback]
Source database DIP
Source database ID DIP-72458E
PMID 20023629
Interaction detection method anti tag coimmunoprecipitation
Host system invitro
Host organism
Cell status
Cell line
Cell type
Tissue type
Comment
Participants
Participant Identification Method Experimental Role Participant Accession
1) HUWE1 unspecified DIP-34362N
2) MCL1 unspecified DIP-231N
Evidence Reference 9
InnateDB ID IDB-330657.1
Last Modified 2012-02-14
Review status Unreviewed by InnateDB [Report errors or provide feedback]
Source database MINT
Source database ID MINT-68752
PMID 16213503
Interaction detection method anti tag coimmunoprecipitation
Host system invivo
Host organism Homo sapiens
Cell status
Cell line
Cell type
Tissue type
Comment vivo
Participants
Participant Identification Method Experimental Role Participant Accession
1) HUWE1 western blot prey Q7Z6Z7
2) MCL1 nucleotide sequence identification bait Q07820
Evidence Reference 10
InnateDB ID IDB-330673.1
Last Modified 2012-02-14
Review status Unreviewed by InnateDB [Report errors or provide feedback]
Source database MINT
Source database ID MINT-68749
PMID 16213503
Interaction detection method anti tag coimmunoprecipitation
Host system invivo
Host organism Homo sapiens
Cell status
Cell line
Cell type
Tissue type
Comment vivo
Participants
Participant Identification Method Experimental Role Participant Accession
1) HUWE1 nucleotide sequence identification prey Q7Z6Z7
2) MCL1 nucleotide sequence identification bait Q07820
Evidence Reference 11
InnateDB ID IDB-330741.1
Last Modified 2012-02-14
Review status Unreviewed by InnateDB [Report errors or provide feedback]
Source database MINT
Source database ID MINT-68753
PMID 16213503
Interaction detection method anti bait coimmunoprecipitation
Host system invivo
Host organism Homo sapiens
Cell status
Cell line
Cell type
Tissue type
Comment vivo
Participants
Participant Identification Method Experimental Role Participant Accession
1) HUWE1 western blot bait Q7Z6Z7
2) MCL1 nucleotide sequence identification prey Q07820
Evidence Reference 12
InnateDB ID IDB-969645.1
Last Modified 2013-07-09
Review status Unreviewed by InnateDB [Report errors or provide feedback]
Source database BIOGRID
Source database ID BIOGRID-685272
PMID 22552282
Interaction detection method affinity chromatography technology
Host system invitro
Host organism
Cell status
Cell line
Cell type
Tissue type
Comment
Participants
Participant Identification Method Experimental Role Participant Accession
1) MCL1 predetermined participant bait 4170
2) HUWE1 predetermined participant prey NP_113584
Evidence Reference 13
InnateDB ID IDB-971105.1
Last Modified 2013-07-09
Review status Unreviewed by InnateDB [Report errors or provide feedback]
Source database BIOGRID
Source database ID BIOGRID-682137
PMID 21298030
Interaction detection method affinity chromatography technology
Host system invitro
Host organism
Cell status
Cell line
Cell type
Tissue type
Comment
Participants
Participant Identification Method Experimental Role Participant Accession
1) MCL1 predetermined participant bait 4170
2) HUWE1 predetermined participant prey NP_113584
Evidence Reference 14
InnateDB ID IDB-971301.1
Last Modified 2013-07-09
Review status Unreviewed by InnateDB [Report errors or provide feedback]
Source database BIOGRID
Source database ID BIOGRID-692386
PMID 19148187
Interaction detection method affinity chromatography technology
Host system invitro
Host organism
Cell status
Cell line
Cell type
Tissue type
Comment
Participants
Participant Identification Method Experimental Role Participant Accession
1) MCL1 predetermined participant bait 4170
2) HUWE1 predetermined participant prey NP_113584
Evidence Reference 15
InnateDB ID IDB-971818.1
Last Modified 2013-07-09
Review status Unreviewed by InnateDB [Report errors or provide feedback]
Source database BIOGRID
Source database ID BIOGRID-685274
PMID 22552282
Interaction detection method affinity chromatography technology
Host system invitro
Host organism
Cell status
Cell line
Cell type
Tissue type
Comment
Participants
Participant Identification Method Experimental Role Participant Accession
1) HUWE1 predetermined participant bait NP_113584
2) MCL1 predetermined participant prey 4170
Evidence Reference 16
InnateDB ID IDB-973179.1
Last Modified 2013-07-09
Review status Unreviewed by InnateDB [Report errors or provide feedback]
Source database BIOGRID
Source database ID BIOGRID-682139
PMID 21298030
Interaction detection method affinity chromatography technology
Host system invitro
Host organism
Cell status
Cell line
Cell type
Tissue type
Comment
Participants
Participant Identification Method Experimental Role Participant Accession
1) HUWE1 predetermined participant bait NP_113584
2) MCL1 predetermined participant prey 4170
Evidence Reference 17
InnateDB ID IDB-1004247.1
Last Modified 2013-07-09
Review status Unreviewed by InnateDB [Report errors or provide feedback]
Source database BIOGRID
Source database ID BIOGRID-729972
PMID 15989957
Interaction detection method affinity chromatography technology
Host system invitro
Host organism
Cell status
Cell line
Cell type
Tissue type
Comment
Participants
Participant Identification Method Experimental Role Participant Accession
1) MCL1 predetermined participant bait 4170
2) HUWE1 predetermined participant prey NP_113584
Evidence Reference 18
InnateDB ID IDB-1053994.1
Last Modified 2013-07-09
Review status Unreviewed by InnateDB [Report errors or provide feedback]
Source database BIOGRID
Source database ID BIOGRID-816463
PMID 21507240
Interaction detection method affinity chromatography technology
Host system invitro
Host organism
Cell status
Cell line
Cell type
Tissue type
Comment
Participants
Participant Identification Method Experimental Role Participant Accession
1) MCL1 predetermined participant bait 4170
2) HUWE1 predetermined participant prey NP_113584
Evidence Reference 19
InnateDB ID IDB-1651274.1
Last Modified 2014-11-29
Review status Unreviewed by InnateDB [Report errors or provide feedback]
Source database INTACT
Source database ID EBI-7836061
PMID 16213503
Interaction detection method anti tag coimmunoprecipitation
Host system invitro
Host organism Homo sapiens
Cell status
Cell line
Cell type
Tissue type
Comment
Participants
Participant Identification Method Experimental Role Participant Accession
1) HUWE1 western blot prey Q7Z6Z7
2) MCL1 nucleotide sequence identification bait Q07820
Evidence Reference 20
InnateDB ID IDB-1651275.1
Last Modified 2014-11-29
Review status Unreviewed by InnateDB [Report errors or provide feedback]
Source database INTACT
Source database ID EBI-7836012
PMID 16213503
Interaction detection method anti tag coimmunoprecipitation
Host system invitro
Host organism Homo sapiens
Cell status
Cell line
Cell type
Tissue type
Comment
Participants
Participant Identification Method Experimental Role Participant Accession
1) HUWE1 nucleotide sequence identification prey Q7Z6Z7
2) MCL1 nucleotide sequence identification bait Q07820
Evidence Reference 21
InnateDB ID IDB-1651277.1
Last Modified 2014-11-29
Review status Unreviewed by InnateDB [Report errors or provide feedback]
Source database INTACT
Source database ID EBI-7836087
PMID 16213503
Interaction detection method anti bait coimmunoprecipitation
Host system invitro
Host organism Homo sapiens
Cell status
Cell line
Cell type
Tissue type
Comment
Participants
Participant Identification Method Experimental Role Participant Accession
1) HUWE1 western blot bait Q7Z6Z7
2) MCL1 nucleotide sequence identification prey Q07820
Evidence Reference 22
InnateDB ID IDB-1728279.1
Last Modified 2014-11-29
Review status Unreviewed by InnateDB [Report errors or provide feedback]
Source database BIOGRID
Source database ID BIOGRID-1029624
PMID 25147182
Interaction detection method affinity chromatography technology
Host system invitro
Host organism
Cell status
Cell line
Cell type
Tissue type
Comment
Participants
Participant Identification Method Experimental Role Participant Accession
1) MCL1 predetermined participant bait 4170
2) HUWE1 predetermined participant prey NP_113584

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca