InnateDB Protein
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IDBP-134624.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Dmtf1
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Protein Name
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cyclin D binding myb-like transcription factor 1
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Synonyms
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Dimp; Dmp1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000092627
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InnateDB Gene
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IDBG-134620 (Dmtf1)
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Protein Structure
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Function |
Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest. May also cooperate with MYB to activate transcription of the ANPEP gene. Binds to the consensus sequence 5'-CCCG[GT]ATGT-3'. {ECO:0000269PubMed:10097151, ECO:0000269PubMed:10898794, ECO:0000269PubMed:11711428, ECO:0000269PubMed:15601844, ECO:0000269PubMed:17936562, ECO:0000269PubMed:8887674, ECO:0000269PubMed:9488476, ECO:0000269PubMed:9786929}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00625, ECO:0000269PubMed:10097151, ECO:0000269PubMed:16878159, ECO:0000269PubMed:17936562, ECO:0000269PubMed:9488476}.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed (at mRNA level). Expressed in brain, intestine, kidney, lung, pancreas, skin, spleen and tongue (at protein level). Expressed at high levels in testis and thymus (at protein level). In all tissues examined, expression is predominant in non-proliferating and differentiated cell types. These include epithelial, interstitial and smooth muscle cells of the intestine, differentiated spermatids, sperm and interstitial cells of the testis, and lymphoid cells of the medullary compartment of the thymus. {ECO:0000269PubMed:10898794, ECO:0000269PubMed:16878159, ECO:0000269PubMed:8887674}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
0
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1344415
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InterPro |
IPR001005
SANT/Myb domain
IPR009057
Homeodomain-like
IPR017877
Myb-like domain
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PFAM |
PF00249
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PRINTS |
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PIRSF |
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SMART |
SM00717
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TIGRFAMs |
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Modification |
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SwissProt |
Q8CE22
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PhosphoSite |
PhosphoSite-Q8CE22
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TrEMBL |
V9GXV6
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UniProt Splice Variant |
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Entrez Gene |
23857
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UniGene |
Mm.395239
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RefSeq |
NP_001103797
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MGI ID |
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MGI Symbol |
Dmtf1
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OMIM |
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CCDS |
CCDS51412
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HPRD |
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IMGT |
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EMBL |
AC107763
AC158121
AK029147
AK031887
AK039563
AK046201
AK160595
BC045141
U70017
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GenPept |
AAC52878
AAH45141
BAC26325
BAC27593
BAC30386
BAC32635
BAE35902
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