InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tlr2

Summary

InnateDB Protein

IDBP-154820.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tlr2

Protein Name

toll-like receptor 2

Synonyms

Ly105;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029623

InnateDB Gene

IDBG-154818 (Tlr2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0008329	signaling pattern recognition receptor activity
GO:0042497	triacyl lipopeptide binding
GO:0042498	diacyl lipopeptide binding
GO:0042834	peptidoglycan binding
GO:0046982	protein heterodimerization activity
GO:0070891	lipoteichoic acid binding
GO:0071723	lipopeptide binding

Biological Process

GO:0001666	response to hypoxia
GO:0001774	microglial cell activation
GO:0002224	toll-like receptor signaling pathway
GO:0002238	response to molecule of fungal origin
GO:0002282	microglial cell activation involved in immune response
GO:0002687	positive regulation of leukocyte migration
GO:0002752	cell surface pattern recognition receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006691	leukotriene metabolic process
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007252	I-kappaB phosphorylation
GO:0008285	negative regulation of cell proliferation
GO:0009617	response to bacterium
GO:0009636	response to toxic substance
GO:0030177	positive regulation of Wnt signaling pathway
GO:0032289	central nervous system myelin formation
GO:0032493	response to bacterial lipoprotein
GO:0032494	response to peptidoglycan
GO:0032496	response to lipopolysaccharide
GO:0032570	response to progesterone
GO:0032695	negative regulation of interleukin-12 production
GO:0032700	negative regulation of interleukin-17 production
GO:0032722	positive regulation of chemokine production
GO:0032733	positive regulation of interleukin-10 production
GO:0032755	positive regulation of interleukin-6 production
GO:0032757	positive regulation of interleukin-8 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0032868	response to insulin
GO:0034123	positive regulation of toll-like receptor signaling pathway
GO:0034134	toll-like receptor 2 signaling pathway
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0042495	detection of triacyl bacterial lipopeptide
GO:0042496	detection of diacyl bacterial lipopeptide
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
GO:0042892	chloramphenicol transport
GO:0044130	negative regulation of growth of symbiont in host
GO:0045087	innate immune response (InnateDB)
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0046209	nitric oxide metabolic process
GO:0048714	positive regulation of oligodendrocyte differentiation
GO:0050715	positive regulation of cytokine secretion
GO:0050729	positive regulation of inflammatory response
GO:0050830	defense response to Gram-positive bacterium
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0052033	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response
GO:0052063	induction by symbiont of defense-related host nitric oxide production
GO:0060907	positive regulation of macrophage cytokine production
GO:0070542	response to fatty acid
GO:0071221	cellular response to bacterial lipopeptide
GO:0071223	cellular response to lipoteichoic acid
GO:0071224	cellular response to peptidoglycan
GO:0071726	cellular response to diacyl bacterial lipopeptide
GO:0071727	cellular response to triacyl bacterial lipopeptide

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0035354	Toll-like receptor 1-Toll-like receptor 2 protein complex
GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex
GO:0042995	cell projection
GO:0044297	cell body

Protein Structure and Domains

PDB ID

MGI:1346060

InterPro

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR017241 Toll-like receptor

PFAM

PF01582
PF13676
PF01463
PF00560
PF13504
PF13855

PRINTS

PIRSF

PIRSF037595

SMART

SM00255
SM00082
SM00369

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt