InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fstl3

Summary

InnateDB Protein

IDBP-170835.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fstl3

Protein Name

follistatin-like 3

Synonyms

E030038F23Rik; Flrg;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020575

InnateDB Gene

IDBG-170833 (Fstl3)

Protein Structure

UniProt Annotation

Function

The secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiation. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. The nuclear form is probably involved in transcriptional regulation via interaction with MLLT10 (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Abundantly expressed in heart, lung, kidney and testis. Continuously expressed in embryonic heart. {ECO:0000269PubMed:17878677}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0005515	protein binding
GO:0048185	activin binding

Biological Process

GO:0001503	ossification
GO:0001822	kidney development
GO:0002244	hematopoietic progenitor cell differentiation
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007283	spermatogenesis
GO:0008584	male gonad development
GO:0022409	positive regulation of cell-cell adhesion
GO:0030324	lung development
GO:0030325	adrenal gland development
GO:0030514	negative regulation of BMP signaling pathway
GO:0032926	negative regulation of activin receptor signaling pathway
GO:0045671	negative regulation of osteoclast differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071248	cellular response to metal ion
GO:0090101	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway