InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppp2ca

Summary

InnateDB Protein

IDBP-170860.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppp2ca

Protein Name

protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform

Synonyms

PP2A; R75353;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020608

InnateDB Gene

IDBG-170858 (Ppp2ca)

Protein Structure

UniProt Annotation

Function

PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:18084284}. Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000269PubMed:18084284}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles (By similarity). Centromeric localization requires the presence of SGOL2. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 164 interaction(s) predicted by orthology.

Experimentally validated
Total	69 [view]
Protein-Protein	69 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	164 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0016787	hydrolase activity
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0050811	GABA receptor binding

Biological Process

GO:0001932	regulation of protein phosphorylation
GO:0006470	protein dephosphorylation
GO:0007126	meiotic nuclear division
GO:0007498	mesoderm development
GO:0010469	regulation of receptor activity
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0031952	regulation of protein autophosphorylation
GO:0042176	regulation of protein catabolic process
GO:0051726	regulation of cell cycle
GO:0070208	protein heterotrimerization
GO:0071902	positive regulation of protein serine/threonine kinase activity

Cellular Component

GO:0000159	protein phosphatase type 2A complex
GO:0000775	chromosome, centromeric region
GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1321159

InterPro

IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00149

PRINTS

PR00114

PIRSF

SMART

SM00156

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt