InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Agfg1

Summary

InnateDB Protein

IDBP-174171.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Agfg1

Protein Name

ArfGAP with FG repeats 1

Synonyms

AU045498; C130049H11Rik; C85612; D730048C23Rik; Hrb; RAB; Rip;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070250

InnateDB Gene

IDBG-174169 (Agfg1)

Protein Structure

UniProt Annotation

Function

Required for vesicle docking or fusion during acrosome biogenesis. May play a role in RNA trafficking or localization. {ECO:0000269PubMed:11711676}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Associated with the cytosolic surface of proacrosomic vesicles of early round spermatids. {ECO:0000269PubMed:11711676}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding

Biological Process

GO:0001675	acrosome assembly
GO:0006810	transport
GO:0007275	multicellular organismal development
GO:0007289	spermatid nucleus differentiation
GO:0032312	regulation of ARF GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0045109	intermediate filament organization

Cellular Component

GO:0005634	nucleus
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0042995	cell projection
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:1333754

InterPro

IPR001164 Arf GTPase activating protein

PFAM

PF01412

PRINTS

PR00405

PIRSF

SMART

SM00105

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K2K6

PhosphoSite

PhosphoSite-Q8K2K6

TrEMBL

UniProt Splice Variant

Entrez Gene

15463

UniGene

RefSeq

MGI ID

MGI Symbol

Agfg1

OMIM

CCDS

HPRD

IMGT

EMBL

AF057287 AK029917 AK048326 AK049400 BC031154

GenPept

AAC97477 AAH31154 BAC26675 BAC33303 BAC33736