Version 5.4
Homo sapiens Protein: IL25
Summary
InnateDB Protein IDBP-235797.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL25
Protein Name interleukin 25
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000380417
InnateDB Gene IDBG-3218 (IL25)
Protein Structure
UniProt Annotation
Function Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0030380 interleukin-17E receptor binding
Biological Process
GO:0006954 inflammatory response
GO:0008150 biological_process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR010345 Interleukin-17 family
IPR029034 Cystine-knot cytokine
PFAM PF06083
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H293
PhosphoSite PhosphoSite-Q9H293
TrEMBL
UniProt Splice Variant
Entrez Gene 64806
UniGene Hs.302036
RefSeq NP_758525
HUGO HGNC:13765
OMIM 605658
CCDS CCDS45086
HPRD 05742
IMGT
EMBL AF305200 AF458059 AF461739 AY359127 BC069565 BC104929 BC104931 CH471078
GenPept AAG40848 AAH69565 AAI04930 AAI04932 AAL57622 AAN39038 AAQ89484 EAW66162

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca