InnateDB Protein
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IDBP-253182.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Odf2
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Protein Name
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outer dense fiber of sperm tails 2
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Synonyms
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AI848335; MMTEST29;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000109393
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InnateDB Gene
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IDBG-154645 (Odf2)
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Protein Structure
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Function |
Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:15852003}. Cell projection, cilium {ECO:0000269PubMed:15852003}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269PubMed:15852003}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269PubMed:15852003}. Note=Localized at the microtubule organizing centers in interphase and spindle poles in mitosis. Localized at the distal/subdistal appendages of mother centrioles.
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Disease Associations |
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Tissue Specificity |
Testis-specific (at protein level). Expressed in spermatids at tubular stage V of the spermatogenic cycle. Highly expressed in the cytoplasm of elongating spermatids (tubular stages X/XI). In step 14/15 spermatids of tubular stage III/IV low expression detected. No expression detected in other testicular cells as well as the early round of spermatids. {ECO:0000269PubMed:9045620, ECO:0000269PubMed:9740324}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005200
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structural constituent of cytoskeleton
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1098824
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
A3KGV1
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PhosphoSite |
PhosphoSite-A3KGV1
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TrEMBL |
Q8CH89
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UniProt Splice Variant |
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Entrez Gene |
18286
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UniGene |
Mm.474899
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RefSeq |
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MGI ID |
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MGI Symbol |
Odf2
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OMIM |
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CCDS |
CCDS15861
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HPRD |
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IMGT |
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EMBL |
AB097861
AF000968
AF034105
AK143726
AK168415
AL928926
BC057001
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GenPept |
AAB65157
AAB87525
AAH57001
BAC44900
BAE25517
BAE40330
CAM46225
CAM46226
CAM46229
CAM46230
CAM46231
CAM46232
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