Version 5.4
Mus musculus Protein: Zfp260
Summary
InnateDB Protein IDBP-265043.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zfp260
Protein Name zinc finger protein 260
Synonyms AI480997; Ozrf1; PEX1; Zfp63; Znf260;
Species Mus musculus
Ensembl Protein ENSMUSP00000103835
InnateDB Gene IDBG-167920 (Zfp260)
Protein Structure
UniProt Annotation
Function Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Predominantly present in heart. Outside the heart, it is detected in embryonic and postnatal vascular smooth muscle cells and in epithelial cells of the lung, gut and kidney at sites of epithelial morphogenesis and in the spinal cord (at protein level). {ECO:0000269PubMed:10449921, ECO:0000269PubMed:16166646}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1347071
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q62513
PhosphoSite PhosphoSite-Q62513
TrEMBL D3Z766
UniProt Splice Variant
Entrez Gene 26466
UniGene Mm.415583
RefSeq
MGI ID
MGI Symbol Zfp260
OMIM
CCDS CCDS21078
HPRD
IMGT
EMBL AC164703 AJ224805 AK088177 AK156219 BC082570 BC085180 D45210
GenPept AAH82570 AAH85180 BAA08144 BAC40191 BAE33630 CAB38535

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca