InnateDB Protein
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IDBP-265043.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Zfp260
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Protein Name
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zinc finger protein 260
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Synonyms
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AI480997; Ozrf1; PEX1; Zfp63; Znf260;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000103835
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InnateDB Gene
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IDBG-167920 (Zfp260)
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Protein Structure
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Function |
Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Predominantly present in heart. Outside the heart, it is detected in embryonic and postnatal vascular smooth muscle cells and in epithelial cells of the lung, gut and kidney at sites of epithelial morphogenesis and in the spinal cord (at protein level). {ECO:0000269PubMed:10449921, ECO:0000269PubMed:16166646}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1347071
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InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
Q62513
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PhosphoSite |
PhosphoSite-Q62513
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TrEMBL |
D3Z766
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UniProt Splice Variant |
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Entrez Gene |
26466
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UniGene |
Mm.415583
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RefSeq |
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MGI ID |
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MGI Symbol |
Zfp260
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OMIM |
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CCDS |
CCDS21078
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HPRD |
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IMGT |
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EMBL |
AC164703
AJ224805
AK088177
AK156219
BC082570
BC085180
D45210
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GenPept |
AAH82570
AAH85180
BAA08144
BAC40191
BAE33630
CAB38535
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