InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDKN1A

Summary

InnateDB Protein

IDBP-295177.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDKN1A

Protein Name

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

Synonyms

CAP20; CDKN1; CIP1; MDA-6; P21; p21CIP1; SDI1; WAF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000384849

InnateDB Gene

IDBG-85033 (CDKN1A)

Protein Structure

UniProt Annotation

Function

May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. {ECO:0000269PubMed:8242751, ECO:0000269PubMed:9106657}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Expressed in all adult tissues, with 5-fold lower levels observed in the brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 469 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	473 [view]
Protein-Protein	403 [view]
Protein-DNA	64 [view]
Protein-RNA	3 [view]
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515	protein binding
GO:0019912	cyclin-dependent protein kinase activating kinase activity
GO:0030332	cyclin binding
GO:0032403	protein complex binding
GO:0046872	metal ion binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007050	cell cycle arrest
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007265	Ras protein signal transduction
GO:0007346	regulation of mitotic cell cycle
GO:0008285	negative regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009411	response to UV
GO:0009636	response to toxic substance
GO:0010033	response to organic substance
GO:0010165	response to X-ray
GO:0010243	response to organonitrogen compound
GO:0010629	negative regulation of gene expression
GO:0014070	response to organic cyclic compound
GO:0030308	negative regulation of cell growth
GO:0030890	positive regulation of B cell proliferation
GO:0031100	organ regeneration
GO:0031668	cellular response to extracellular stimulus
GO:0033158	regulation of protein import into nucleus, translocation
GO:0034605	cellular response to heat
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042326	negative regulation of phosphorylation
GO:0042493	response to drug
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043066	negative regulation of apoptotic process
GO:0043068	positive regulation of programmed cell death
GO:0045087	innate immune response
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045860	positive regulation of protein kinase activity
GO:0046685	response to arsenic-containing substance
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048146	positive regulation of fibroblast proliferation
GO:0051384	response to glucocorticoid
GO:0051412	response to corticosterone
GO:0051726	regulation of cell cycle
GO:0055093	response to hyperoxia
GO:0060574	intestinal epithelial cell maturation
GO:0071479	cellular response to ionizing radiation
GO:0071850	mitotic cell cycle arrest
GO:0071901	negative regulation of protein serine/threonine kinase activity
GO:0090398	cellular senescence
GO:0090400	stress-induced premature senescence
GO:0097193	intrinsic apoptotic signaling pathway
GO:2000278	regulation of DNA biosynthetic process
GO:2000379	positive regulation of reactive oxygen species metabolic process

Cellular Component

GO:0000307	cyclin-dependent protein kinase holoenzyme complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm
GO:0070557	PCNA-p21 complex